Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 2/20 | 0.53 |
| ▸ | AKR1C3 | P42330 | 9/20 | 0.49 |
| ▸ | AKR1C2 | P52895 | 9/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.41 |
| ▸ | PRNP | P04156 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.40 |
| ▸ | FABP2 | P12104 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11780974 | 0.84 | AKR1B1 (0.57) | AKR1B1AKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL11735345 | 0.79 | DRD1 (0.36) | AKR1B1AKR1C3AKR1C2PRNPRXFP1 | |
| SCHEMBL11458752 | 0.75 | AKR1B1 (0.60) | AKR1B1AKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL11470668 | 0.72 | AKR1B1 (0.57) | AKR1B1AKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL11736891 | 0.71 | AKR1B1 (0.59) | AKR1B1AKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL11535815 | 0.71 | AKR1C3 (0.69) | AKR1B1AKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL11270273 | 0.70 | AKR1B1 (1.00) | AKR1B1AKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL11478113 | 0.69 | HPGD (0.42) | MAPTMEN1KMT2AHPGDTSHR | |
| SCHEMBL28540948 | 0.69 | AKR1B1 (0.58) | AKR1B1AKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL12431128 | 0.69 | AKR1B1 (0.69) | AKR1B1AKR1C3AKR1C2PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4045485-A | ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC AND ANTIPRURITIC ACTIVITY | SYNTEX CORPORATION (US) | 1977-08-30 | — | — | US | disclosed |
| US-3960936-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIPYRETICS, SKIN DISORDERS | SYNTEX CORPORATION (PM) | 1976-06-01 | — | — | US | disclosed |
| US-3947472-A | ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC, ANTIPRURITIC | SYNTEX CORPORATION (PM) | 1976-03-30 | — | — | US | disclosed |
| US-3935273-A | ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC, ANTIPRURITIC | SYNTEX CORPORATION (US) | 1976-01-27 | — | — | US | disclosed |