SCHEMBL11458786

SCHEMBL11458786

Oc1ccc(O)c2c1C1(Cl)C(Cl)=C(Cl)C2(Cl)C1(Cl)Cl

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 1/20 1.00
MAPK1 P28482 2/20 0.33
CYP3A4 P08684 1/20 0.33
TSHR P16473 2/20 0.32
HSD17B10 Q99714 2/20 0.32
ALOX5 P09917 1/20 0.30
ALDH1A1 P00352 1/20 0.30
HPGD P15428 1/20 0.30
ALOX15 P16050 1/20 0.30
ALOX12 P18054 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30
CA1 P00915 1/20 0.30
CA2 P00918 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11477758 0.76 HSP90AA1 (0.61) HSP90AA1
SCHEMBL11467672 0.76 HSP90AA1 (0.61) HSP90AA1
SCHEMBL11499029 0.73 HSP90AA1 (0.57) HSP90AA1MAPK1CYP3A4HSD17B10ALOX5
SCHEMBL11460284 0.72 HSP90AA1 (0.53) HSP90AA1MAPK1CYP3A4ALDH1A1SMN1; SMN2
SCHEMBL11469523 0.63 HSP90AA1 (0.46) HSP90AA1CYP3A4TSHRALDH1A1
SCHEMBL11465606 0.62 HSP90AA1 (0.45) HSP90AA1
SCHEMBL8865294 0.61 HSP90AA1 (0.44) HSP90AA1
SCHEMBL7743436 0.58 CYP3A4 (0.75) HSP90AA1MAPK1CYP3A4TSHRHSD17B10
SCHEMBL68064 0.58 CYP3A4 (0.75) HSP90AA1MAPK1CYP3A4TSHRHSD17B10
SCHEMBL31392414 0.58 CYP3A4 (0.75) HSP90AA1MAPK1CYP3A4TSHRHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4240974-A 1,2,3,4,9,9-HEXAHALO-1,4-DIHYDRO-1,4-METHANO-NAPHTHALENE-5,8 -DISULFONATE LITTLE JULIAN R (US) 1980-12-23 US disclosed
US-4174457-A Carbamate UNIROYAL, INC. (US) 1979-11-13 US disclosed
US-4080408-A FIRE RETARDANTS UNIROYAL, INC. (US) 1978-03-21 US disclosed
US-4058568-A FIRE RETARDANT UNIROYAL, INC. (US) 1977-11-15 US disclosed
US-4009200-A FIREPROOFING POLYMERS UNIROYAL, INC. (US) 1977-02-22 US disclosed
US-3998913-A ABS TERPOLYMER AND A MOLECULAR COMPLEX OF 1,2,3,4,9,9-HEXACHLORO-1,4-DIHYDRO-1,4-METHANONAPHTHALENE-5,8-DIOL UNIROYAL INC. (US) 1976-12-21 US disclosed
US-3932525-A FIREPROOFING ABS RESINS UNIROYAL INC. (US) 1976-01-13 US disclosed