Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.38 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.38 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.38 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1146054 | 0.86 | MAPK1 (0.56) | MAPK8KDM4EMAPK1HSD17B10SMN1; SMN2 | |
| Dimethylamine SCHEMBL9149936 | 0.82 | MAPK1 (0.51) | MAPK8KDM4EMAPK1HSD17B10SMN1; SMN2 | |
| SCHEMBL1145868 | 0.81 | KDM4E (0.45) | MAPK8KDM4EHSD17B10SMN1; SMN2MEN1 | |
| SCHEMBL11447309 | 0.79 | MAPK8 (0.62) | MAPK8KDM4EHSD17B10HPGDALDH1A1 | |
| SCHEMBL8766034 | 0.76 | NOS1 (0.47) | MAPK8KDM4EMAPK1HSD17B10GAA | |
| SCHEMBL1144839 | 0.75 | MAPK8 (0.78) | MAPK8MAPK9PRKD3MAP4K4MAP4K2 | |
| SCHEMBL11702984 | 0.74 | MAPK8 (0.43) | MAPK8KDM4EGAASMN1; SMN2MEN1 | |
| SCHEMBL7893174 | 0.74 | KDM4E (0.48) | KDM4EMAPK1HSD17B10GAARECQL | |
| SCHEMBL1145009 | 0.74 | MAPK8 (0.60) | MAPK8MAPK1MAPK9PRKD3MAP4K4 | |
| SCHEMBL21610059 | 0.73 | KDM4E (0.42) | KDM4EMAPK1HSD17B10SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7888374-B2 | Inhibitors of c-jun N-terminal kinases | ABBOTT LABORATORIES (US) | 2011-02-15 | — | — | US | disclosed |
| US-20060173050-A1 | Inhibitors of c-Jun N-terminal kinases | ABBVIE INC. | 2006-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060173050-A1 | Inhibitors of c-Jun N-terminal kinases | MAPKAPK3, MAP3K3, MAPK3 | MAPK8 30/4885KDM4E 2987/4885MAPK1 26/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.