Sugi Predict

Sugi Predict / Targets / NOS1

NOS1

Nitric oxide synthase 1 · P29475 · NOS1 on Sugi Atlas →

136,168 patent compounds predicted against NOS1, 60,717 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL80890 SCHEMBL80890 0.54 10/20
SCHEMBL43288 SCHEMBL43288 0.73 9/20
Arginine Arginine (SCHEMBL43261) 0.72 9/20
SCHEMBL156221 SCHEMBL156221 0.68 9/20
SCHEMBL59519 SCHEMBL59519 0.49 9/20
SCHEMBL59520 SCHEMBL59520 0.49 9/20
SCHEMBL126967 SCHEMBL126967 0.56 8/20
Pterine Pterine (SCHEMBL64320) 0.51 8/20
SCHEMBL156195 SCHEMBL156195 0.50 8/20
SCHEMBL66137 SCHEMBL66137 0.49 8/20
SCHEMBL155255 SCHEMBL155255 1.00 7/20
SCHEMBL145755 SCHEMBL145755 0.50 7/20
Indazole Indazole (SCHEMBL108997) 0.48 7/20
Indazole Indazole (SCHEMBL110751) 0.48 7/20
Ornithine Aketoglutarate Ornithine Aketoglutarate (SCHEMBL53032) 0.42 7/20
Ornithine Ornithine (SCHEMBL53033) 0.42 7/20
SCHEMBL104360 SCHEMBL104360 1.00 6/20
SCHEMBL160399 SCHEMBL160399 0.73 6/20
Sapropterin Sapropterin (SCHEMBL37480) 0.65 6/20
SCHEMBL36008 SCHEMBL36008 0.56 6/20

Clinical trials — most relevant to NOS1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Nebivolol Effect on Nitric Oxide Levels, Blood Pressure, and Renal Function in Kidney Transplant Patients PHASE4COMPLETED
Sickle Cell Disease Treatment With Arginine Therapy (STArT) Trial PHASE3COMPLETED
L-Arginine in Pre-Eclampsia PHASE3COMPLETED
Methylene Blue in Early Septic Shock PHASE2/PHASE3COMPLETED
COMP-4 Supplementation and Brachial Artery FMD PHASE1/PHASE2COMPLETED
Networked Drug REpurposing for Mechanism-based neuroPrOtection in Acute Ischaemic STROKE PHASE2UNKNOWN
Minocyclin in Ulcerative Colitis as Added on Therapy PHASE2COMPLETED
Evaluation of Two Doses of Nitric Oxide (NO) Given Intermittently Via Inhalation to Subjects With Bronchiolitis PHASE2COMPLETED
STRETCH Study: Effect of Distensibility on Endothelial-Dependent Vasoreactivity in Patients With ISH PHASE2COMPLETED
Intravenous L-Citrulline Influence on the Need for Invasive Mechanical Ventilation for Acute Hypoxemic Respiratory Failure in Patients With COVID-19 PHASE2COMPLETED
The STRETCH Study: Distensibility on Endothelial-Dependent Vasoreactivity in Subjects With Systolic Hypertension PHASE2COMPLETED
Simvastatin in Secondary Progressive Multiple Sclerosis PHASE2COMPLETED
Response to Exercise and Nitric Oxide in PAD PHASE2RECRUITING
Possible Effects of Propylthiouracil, Riociguat and Perphenazine on Circulation of Healthy Volunteers PHASE1COMPLETED
Influence of Dietary Nitrate on Skin Inflammation PHASE1COMPLETED
Effect of Simvastatin on CF Airway Inflammation PHASE1COMPLETED
Impact of NOS, COX, and ROS Inhibition on Cerebral Blood Flow Regulation PHASE1WITHDRAWN
L-Citrulline and Endothelial Function PHASE1COMPLETED
iNOS With Positron Emission Tomography (PET) in Cellular Inflammation. EARLY_PHASE1COMPLETED
Fetal Alcohol Spectrum Disorder-Is This a Ciliopathy? nanCOMPLETED
The Clinical Value of the Nitric Oxide System Components in Asthma and COPD nanUNKNOWN
The Acute Effect of a Walnut Intervention on Cognitive Performance, Brain Activation, and Serum Markers of Inflammation in Young Adults nanCOMPLETED
OrthoCor Advanced Trial for Knee Osteoarthritis nanCOMPLETED
Systemic Nitrosative/Oxidative Stress in Patients with Acute Brain Injury nanUNKNOWN
Detection and Use of Nasal Nitrous Oxide and the Electronic Nose nanCOMPLETED
NO Donors and Inhibitors to Study Imbalance of Nitrogen Stress and Antioxidant Defense in COPD nanCOMPLETED
Effects of Trehalose and Polyphenols in Vasculopathic Patients nanCOMPLETED
Nitrate Supplementation and Exercise Tolerance in Patients With Type 2 Diabetes nanCOMPLETED
Thyme Honey Mouthwash in Management of Periodontitis in Renal Patients nanCOMPLETED
Effect of a Non-pharmacological Intervention on Endothelial Function, Body Composition, and Physical Functionality in Recovered COVID-19 Patients. nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a NOS1 binder may also engage these)

ProteinNameSimilarity
Q9Z0J4 — 1.000 Q9Z0J4 →
O19132 — 1.000 O19132 →
P29476 — 1.000 P29476 →
Q29498 — 1.000 Q29498 →
Q27571 — 0.997 Q27571 →
P11806 — 0.996 P11806 →
Q8RXS6 — 0.995 Q8RXS6 →
O61608 — 0.995 O61608 →
P86937 — 0.994 P86937 →
P0C570 — 0.994 P0C570 →
P97588 — 0.994 P97588 →
O76616 — 0.994 O76616 →
P24741 — 0.994 P24741 →
B4Q0P1 — 0.993 B4Q0P1 →
Q9V3D2 — 0.993 Q9V3D2 →
Q9WH76 — 0.993 Q9WH76 →
Q06502 — 0.993 Q06502 →
Q09110 — 0.993 Q09110 →
Q9D992 — 0.993 Q9D992 →
F1QGC8 — 0.993 F1QGC8 →
Q8AZM0 — 0.993 Q8AZM0 →
Q6AX58 — 0.993 Q6AX58 →
P20867 — 0.993 P20867 →
PHKB Phosphorylase kinase beta subunit 0.992 landscape →
P19501 — 0.992 P19501 →
Q9YN02 — 0.992 Q9YN02 →
P20886 — 0.992 P20886 →
P0DJV7 — 0.992 P0DJV7 →
Q5VKP6 — 0.992 Q5VKP6 →
G5EED4 — 0.992 G5EED4 →