Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Silver. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5487129 | 0.95 | HSD11B1 (0.45) | HSD11B1L3MBTL1EPHX1EPHX2HTT | |
| Potassium Ion SCHEMBL5492277 | 0.95 | HSD11B1 (0.45) | HSD11B1L3MBTL1EPHX1EPHX2HTT | |
| SCHEMBL5489936 | 0.95 | HSD11B1 (0.45) | HSD11B1L3MBTL1EPHX1EPHX2HTT | |
| SCHEMBL19348554 | 0.95 | HSD11B1 (0.45) | HSD11B1L3MBTL1EPHX1EPHX2HTT | |
| SCHEMBL19348563 | 0.95 | HSD11B1 (0.45) | HSD11B1L3MBTL1EPHX1EPHX2HTT | |
| SCHEMBL957639 | 0.95 | HSD11B1 (0.45) | HSD11B1L3MBTL1EPHX1EPHX2HTT | |
| SCHEMBL17332127 | 0.95 | HSD11B1 (0.45) | HSD11B1L3MBTL1EPHX1EPHX2HTT | |
| Lithium Ion SCHEMBL5489642 | 0.95 | HSD11B1 (0.45) | HSD11B1L3MBTL1EPHX1EPHX2HTT | |
| SCHEMBL5487493 | 0.95 | HTT (0.45) | HSD11B1L3MBTL1EPHX1EPHX2HTT | |
| SCHEMBL4389272 | 0.95 | HSD11B1 (0.45) | HSD11B1L3MBTL1EPHX1EPHX2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2610248-B1 | METHOD FOR PRODUCING PHENYL-SUBSTITUTED HETEROCYCLIC DERIVATIVE BY MEANS OF COUPLING METHOD USING A PALLADIUM COMPOUND | TEIJIN PHARMA LTD (JP) | 2016-06-08 | — | — | EP | claimed |
| US-9803098-B2 | Conductive ink | PESOLVE CO., LTD. (KR) | 2017-10-31 | — | — | US | disclosed |
| US-20160185990-A1 | CONDUCTIVE INK | YMT CO.,LTD. (KR) | 2016-06-30 | — | — | US | disclosed |
| US-4188274-A | DECARBOXYLATION | STANDARD OIL COMPANY (INDIANA) (US) | 1980-02-12 | — | — | US | disclosed |
| US-4174447-A | SILVER SALTS OF CARBOXY ACIDS | STANDARD OIL COMPANY (INDIANA) (US) | 1979-11-13 | — | — | US | disclosed |