Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 20/20 | 0.76 |
| ▸ | PRKCD | Q05655 | 20/20 | 0.76 |
| ▸ | LYN | P07948 | 9/20 | 0.74 |
| ▸ | LCK | P06239 | 2/20 | 0.74 |
| ▸ | PRKCB | P05771 | 1/20 | 0.74 |
| ▸ | PRKCH | P24723 | 1/20 | 0.74 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2981772 | 0.86 | PRKCQ (1.00) | PRKCQPRKCDLYNLCKPRKCB | |
| SCHEMBL4947443 | 0.85 | PRKCQ (1.00) | PRKCQPRKCDLYNLCKPRKCB | |
| SCHEMBL5520795 | 0.85 | PRKCQ (0.77) | PRKCQPRKCDLYNLCKPRKCB | |
| SCHEMBL1146445 | 0.84 | PRKCQ (0.71) | PRKCQPRKCDLYNLCKPRKCB | |
| SCHEMBL5516592 | 0.84 | PRKCQ (0.73) | PRKCQPRKCDLYNLCKPRKCB | |
| SCHEMBL5514023 | 0.82 | PRKCQ (0.72) | PRKCQPRKCDLYNLCKPRKCB | |
| SCHEMBL5520416 | 0.81 | PRKCQ (1.00) | PRKCQPRKCDLYNLCKPRKCB | |
| SCHEMBL1146073 | 0.79 | PRKCQ (0.75) | PRKCQPRKCDLYNLCK | |
| SCHEMBL2929021 | 0.79 | PRKCQ (0.68) | PRKCQPRKCDLYNLCKPRKCB | |
| SCHEMBL2929018 | 0.79 | PRKCQ (0.68) | PRKCQPRKCDLYNLCKPRKCB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110028455-A1 | Indole-substituted 3-cyanopyridines As Kinase Inhibitors | WYETH LLC (US) | 2011-02-03 | — | — | US | claimed |
| EP-2229376-A1 | INDOLE-SUBSTITUTED 3-CYANOPYRIDINES AS KINASE INHIBITORS | Wyeth LLC (US) | 2010-09-22 | — | — | EP | claimed |
| WO-2009076571-A1 | INDOLE-SUBSTITUTED 3-CYANOPYRIDINES AS KINASE INHIBITORS | WYETH (US) | 2009-06-18 | — | — | WO | claimed |
| US-20110028455-A1 | Indole-substituted 3-cyanopyridines As Kinase Inhibitors | WYETH LLC (US) | 2011-02-03 | — | — | US | disclosed |
| US-20110028455-A1 | Indole-substituted 3-cyanopyridines As Kinase Inhibitors | WYETH LLC (US) | 2011-02-03 | — | — | US | disclosed |
| US-20110028455-A1 | Indole-substituted 3-cyanopyridines As Kinase Inhibitors | WYETH LLC (US) | 2011-02-03 | — | — | US | disclosed |
| EP-2229376-A1 | INDOLE-SUBSTITUTED 3-CYANOPYRIDINES AS KINASE INHIBITORS | Wyeth LLC (US) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009076571-A1 | INDOLE-SUBSTITUTED 3-CYANOPYRIDINES AS KINASE INHIBITORS | WYETH (US) | 2009-06-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110028455-A1 | Indole-substituted 3-cyanopyridines As Kinase Inhibitors | CNKSR1, CSNK1G3, GRK3 | PRKCQ 324/4885PRKCD 291/4885LYN 133/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.