Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.34 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30462623 | 0.82 | — | — | |
| SCHEMBL116392 | 0.82 | — | — | |
| Bromide SCHEMBL25319134 | 0.80 | CYP11B1 (0.44) | CYP11B1CYP11B2GRIN1GRIN2BCYP2E1 | |
| SCHEMBL15516735 | 0.78 | CYP11B1 (0.43) | CYP11B1CYP11B2GRM2HTR2AKCNH2 | |
| SCHEMBL3635565 | 0.78 | TAAR1 (0.52) | CYP11B1CYP11B2TDP1HTR2ACYP2A6 | |
| SCHEMBL10282267 | 0.78 | SMN1; SMN2 (0.49) | CYP11B1CYP11B2TDP1MEN1KMT2A | |
| SCHEMBL10483862 | 0.78 | CYP11B1 (0.43) | CYP11B1CYP11B2GRM2HTR2AKCNH2 | |
| SCHEMBL115263 | 0.78 | CYP11B1 (0.43) | CYP11B1CYP11B2TDP1GRM2HTR2A | |
| SCHEMBL2533763 | 0.76 | CYP11B1 (0.44) | CYP11B1TDP1GRM2MEN1KMT2A | |
| SCHEMBL9156125 | 0.75 | SMN1; SMN2 (0.46) | CYP11B1CYP11B2TDP1GRM2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3774789-A1 | BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE | Arvinas Operations, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |
| WO-2019195201-A1 | BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2019-10-10 | — | — | WO | disclosed |
| EP-2424859-A1 | INHIBITORS OF PI3 KINASE AND / OR MTOR | Amgen, Inc (US) | 2012-03-07 | — | — | EP | disclosed |
| WO-2010126895-A1 | INHIBITORS OF PI3 KINASE AND / OR MTOR | AMGEN INC. (US) | 2010-11-04 | — | — | WO | disclosed |
| CN-100343233-C | Malononitrile compounds and their use | SUMITOMO CHEMICAL CO (JP) | 2007-10-17 | — | — | CN | disclosed |