SCHEMBL3635565

SCHEMBL3635565

NCCc1ccc(F)nc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 8/20 0.52
MAOB P27338 2/20 0.45
CHRNA7 P36544 1/20 0.45
CYP11B1 P15538 1/20 0.43
CYP11B2 P19099 1/20 0.43
CYP1A2 P05177 2/20 0.41
CYP2A6 P11509 1/20 0.41
LOXL2 Q9Y4K0 1/20 0.41
KDM4E B2RXH2 1/20 0.41
ALDH1A1 P00352 1/20 0.41
HTR1A P08908 1/20 0.41
ADRA2A P08913 1/20 0.41
SLC6A2 P23975 1/20 0.41
CYP2C19 P33261 1/20 0.41
HTR3A P46098 1/20 0.41
BACE1 P56817 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
HTR2A P28223 1/20 0.41
BLM P54132 1/20 0.40
KMT2A Q03164 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23124232 0.88 CYP2A6 (0.48) TAAR1MAOBCYP11B1CYP11B2CYP1A2
SCHEMBL29745082 0.88 CYP2A6 (0.48) TAAR1MAOBCYP11B1CYP11B2CYP1A2
SCHEMBL29726521 0.82
SCHEMBL1145463 0.82
SCHEMBL10483864 0.81 SIGMAR1 (0.47) TAAR1CYP11B1CYP11B2SLC6A2KMT2A
Hydrochloric Acid SCHEMBL5009749 0.80 LOXL2 (0.47) MAOBCYP11B1CYP11B2LOXL2
SCHEMBL115263 0.78 CYP11B1 (0.43) CYP11B1CYP11B2CYP1A2CYP2A6KDM4E
SCHEMBL15516735 0.78 CYP11B1 (0.43) CYP11B1CYP11B2CYP2A6HTR2ATP53
SCHEMBL10483862 0.78 CYP11B1 (0.43) CYP11B1CYP11B2CYP2A6HTR2A
SCHEMBL10282267 0.78 SMN1; SMN2 (0.49) CYP11B1CYP11B2CYP1A2KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2155735-A2 TRIAZOLYL AMINOPYRIMIDINE COMPOUNDS ELI LILLY AND COMPANY (US) 2010-02-24 EP disclosed
EP-2125794-A1 IMIDAZOLIDINONYL AMINOPYRIMIDINE COMPOUNDS FOR THE TREATMENT OF CANCER Eli Lilly & Company (US) 2009-12-02 EP disclosed
WO-2008144222-A2 TRIAZOLYL AMINOPYRIMIDINE COMPOUNDS ELI LILLY AND COMPANY (US) 2008-11-27 WO disclosed
WO-2008076705-A1 IMIDAZOLIDINONYL AMINOPYRIMIDINE COMPOUNDS FOR THE TREATMENT OF CANCER ELI LILLY AND COMPANY (US) 2008-06-26 WO disclosed
EP-1846394-A1 PYRAZOLYLAMINOPYRIDINE DERIVATIVES USEFUL AS KINASE INHIBITORS AstraZeneca AB (SE) 2007-10-24 EP disclosed
WO-2006082392-A1 PYRAZOLYLAMINOPYRIDINE DERIVATIVES USEFUL AS KINASE INHIBITORS ASTRAZENECA AB (SE) 2006-08-10 WO disclosed