Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 3/20 | 0.55 |
| ▸ | GFER | P55789 | 2/20 | 0.53 |
| ▸ | DRD2 | P14416 | 4/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | DRD3 | P35462 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11456513 | 0.99 | DRD4 (0.54) | DRD4GFERDRD2HTR2AMAPT | |
| SCHEMBL11446739 | 0.92 | DRD4 (0.53) | DRD4GFERDRD2HTR2AMAPT | |
| SCHEMBL11447094 | 0.92 | GFER (0.56) | DRD4GFERDRD2HTR2AMAPT | |
| SCHEMBL11447939 | 0.91 | GFER (0.55) | DRD4GFERDRD2HTR2AMAPT | |
| SCHEMBL11465416 | 0.89 | DRD4 (0.60) | DRD4GFERDRD2MAPTTP53 | |
| SCHEMBL11454261 | 0.88 | HTR7 (0.56) | DRD4DRD2HTR2AMAPTDRD3 | |
| SCHEMBL11457057 | 0.88 | DRD4 (0.59) | DRD4GFERDRD2MAPTTP53 | |
| SCHEMBL11447014 | 0.87 | HTR7 (0.55) | DRD4DRD2HTR2AMAPTDRD3 | |
| SCHEMBL11455011 | 0.87 | DRD4 (0.58) | DRD4GFERDRD2HTR2AMAPT | |
| SCHEMBL11465661 | 0.86 | DRD4 (0.59) | DRD4GFERDRD2MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4205173-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1980-05-27 | — | — | US | disclosed |
| US-4085107-A | ANALGESICS | PENNWALT CORPORATION (US) | 1978-04-18 | — | — | US | disclosed |
| US-4060526-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1977-11-29 | — | — | US | disclosed |