SCHEMBL11467720

SCHEMBL11467720

CCCC(CC)C(=O)CCl

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 2/20 0.50
HDAC2 Q92769 2/20 0.50
CHRM1 P11229 2/20 0.50
CHRM3 P20309 2/20 0.50
ADRA1A P35348 2/20 0.50
AKR1A1 P14550 1/20 0.50
HTR2A P28223 1/20 0.50
HTR2C P28335 1/20 0.50
HRH1 P35367 1/20 0.50
DRD3 P35462 1/20 0.50
SLC6A3 Q01959 1/20 0.50
TDP1 Q9NUW8 1/20 0.50
TSHR P16473 3/20 0.48
CYP3A4 P08684 2/20 0.48
NFKB1 P19838 2/20 0.48
NPSR1 Q6W5P4 2/20 0.48
HDAC7 Q8WUI4 2/20 0.44
HDAC8 Q9BY41 2/20 0.44
HDAC6 Q9UBN7 2/20 0.44
HDAC9 Q9UKV0 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4992713 0.90 HDAC1 (0.55) HDAC1HDAC2CHRM1CHRM3ADRA1A
SCHEMBL11465778 0.86 CA2 (0.61) TSHRCA2MAPK1CA1USP2
SCHEMBL11457543 0.84
SCHEMBL7598232 0.82 CHRM1 (0.52) HDAC1HDAC2CHRM1CHRM3ADRA1A
SCHEMBL23175836 0.81 CA2 (0.50) HDAC1HDAC2CHRM1CHRM3ADRA1A
SCHEMBL19679638 0.80 HDAC7 (0.50) HDAC1HDAC2CHRM1CHRM3ADRA1A
SCHEMBL20838325 0.80 HDAC1 (0.50) HDAC1HDAC2CHRM1CHRM3ADRA1A
SCHEMBL9987438 0.80 HDAC1 (0.50) HDAC1HDAC2CHRM1CHRM3ADRA1A
SCHEMBL30601096 0.78 CHRM1 (0.48) HDAC1HDAC2CHRM1CHRM3ADRA1A
SCHEMBL1410417 0.77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4240983-A HALOGENATION BAYER AKTIENGESELLSCHAFT (DE) 1980-12-23 US disclosed