Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | CHAT | P28329 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 2/20 | 0.35 |
| ▸ | GSR | P00390 | 1/20 | 0.35 |
| ▸ | DRD5 | P21918 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11468144 | 1.00 | ADRA2A (0.46) | ADRA2AADRA2BADRA2CCHATDRD2 | |
| SCHEMBL11469930 | 0.81 | KDM4E (0.46) | CHATKDM4ESMN1; SMN2ALDH1A1DRD1 | |
| SCHEMBL11469931 | 0.81 | KDM4E (0.46) | CHATKDM4ESMN1; SMN2ALDH1A1DRD1 | |
| SCHEMBL11792003 | 0.76 | CHAT (0.64) | ADRA2AADRA2BADRA2CCHATALDH1A1 | |
| SCHEMBL11791997 | 0.76 | CHAT (0.64) | ADRA2AADRA2BADRA2CCHATALDH1A1 | |
| SCHEMBL11470364 | 0.71 | ADRA2A (0.46) | ADRA2AADRA2BADRA2CDRD2DRD4 | |
| SCHEMBL1388074 | 0.70 | DRD4 (0.62) | ADRA2AADRA2BADRA2CDRD2DRD4 | |
| SCHEMBL8430910 | 0.68 | KDM4E (0.48) | KDM4ESMN1; SMN2L3MBTL1 | |
| SCHEMBL8430912 | 0.68 | KDM4E (0.48) | KDM4ESMN1; SMN2L3MBTL1 | |
| SCHEMBL11795510 | 0.68 | SMN1; SMN2 (0.51) | CHATKDM4ESMN1; SMN2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4208415-A | PROSTAGLANDIN POTENTIATORS, 15-A-HYDROXYPROSTAGLANDIN DEHYDROGENASE INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1980-06-17 | — | — | US | claimed |
| US-4208415-A | PROSTAGLANDIN POTENTIATORS, 15-A-HYDROXYPROSTAGLANDIN DEHYDROGENASE INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1980-06-17 | — | — | US | disclosed |