Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL11467409 | 1.00 | ALDH1A1 (0.42) | ALDH1A1HSD17B10MEN1KMT2ATHRB | |
| Propylene Glycol SCHEMBL11457839 | 0.87 | ALDH1A1 (0.42) | ALDH1A1HSD17B10MEN1KMT2ATHRB | |
| Propylene Glycol SCHEMBL11467351 | 0.87 | ALDH1A1 (0.42) | ALDH1A1HSD17B10MEN1KMT2ATHRB | |
| SCHEMBL829291 | 0.86 | MEN1 (0.50) | ALDH1A1HSD17B10MEN1KMT2ATHRB | |
| SCHEMBL98075 | 0.86 | MEN1 (0.50) | ALDH1A1HSD17B10MEN1KMT2ATHRB | |
| SCHEMBL829630 | 0.86 | MEN1 (0.50) | ALDH1A1HSD17B10MEN1KMT2ATHRB | |
| SCHEMBL679835 | 0.86 | MEN1 (0.50) | ALDH1A1HSD17B10MEN1KMT2ATHRB | |
| SCHEMBL64957 | 0.86 | MEN1 (0.50) | ALDH1A1HSD17B10MEN1KMT2ATHRB | |
| SCHEMBL9720673 | 0.86 | MEN1 (0.50) | ALDH1A1HSD17B10MEN1KMT2ATHRB | |
| SCHEMBL829553 | 0.86 | MEN1 (0.50) | ALDH1A1HSD17B10MEN1KMT2ATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4192759-A | Automotive brake fluid compositions including semipolar borates and heteroborates | TOHO CHEMICAL INDUSTRY CO., LTD. (JP) | 1980-03-11 | — | — | US | disclosed |