Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRR1 | P24046 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.41 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.41 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | CACNA2D2 | Q9NY47 | 1/20 | 0.41 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.37 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.37 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | GABRP | O00591 | 2/20 | 0.36 |
| ▸ | GABRD | O14764 | 2/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL4737976 | 0.90 | GABRR1 (0.46) | GABRR1LMNATP53CACNA2D1CACNB3 | |
| Bicarbonate SCHEMBL10950732 | 0.90 | — | — | |
| Acetic Acid SCHEMBL27861656 | 0.88 | FFAR3 (0.44) | GABRR1LMNATP53CACNA2D1CACNB3 | |
| Carbamic Acid SCHEMBL10943380 | 0.88 | — | — | |
| Acetic Acid SCHEMBL2678979 | 0.88 | — | — | |
| Carbamic Acid SCHEMBL23725741 | 0.88 | — | — | |
| Acetic Acid SCHEMBL11456389 | 0.85 | GABRR1 (0.42) | GABRR1LMNATP53CACNA2D1CACNB3 | |
| Lactic Acid SCHEMBL7803238 | 0.85 | TP53 (0.65) | GABRR1LMNATP53CACNA2D1CACNB3 | |
| Oxalic Acid SCHEMBL20162291 | 0.84 | CACNA2D1 (0.48) | GABRR1LMNACACNA2D1CACNB3CACNA1C | |
| Methacrylic Acid SCHEMBL28645739 | 0.84 | TDP1 (0.39) | GABRR1LMNATP53CACNA2D1CACNB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4181661-A | SCHIZOPHRENIA, PSYCHOLOGICAL DISORDERS | MERCK & CO., INC. (US) | 1980-01-01 | — | — | US | disclosed |
| US-4029803-A | Method of treatment with 2-iminothiazolidines and thiazolines | MERCK & CO., INC. (US) | 1977-06-14 | — | — | US | disclosed |