Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.41 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.41 |
| ▸ | CHUK | O15111 | 2/20 | 0.38 |
| ▸ | LATS1 | O95835 | 3/20 | 0.37 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30070982 | 0.77 | CYP1A2 (0.59) | IMPDH2GAAKDM4ELMNACYP1A2 | |
| SCHEMBL3805113 | 0.77 | CYP1A2 (0.59) | IMPDH2GAAKDM4ELMNACYP1A2 | |
| SCHEMBL197273 | 0.76 | CYP2A6 (0.52) | GAAKDM4ECYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL29787086 | 0.76 | CHUK (0.50) | IMPDH2GAANFATC1GSK3BDYRK1A | |
| SCHEMBL2243252 | 0.76 | CHUK (0.50) | IMPDH2GAANFATC1GSK3BDYRK1A | |
| Hydrochloric Acid SCHEMBL2240661 | 0.74 | CHUK (0.49) | IMPDH2GAANFATC1GSK3BDYRK1A | |
| SCHEMBL21917251 | 0.74 | IMPDH2 (0.43) | IMPDH2GAADYRK1AKDM4ELMNA | |
| SCHEMBL6804952 | 0.73 | IMPDH2 (0.66) | IMPDH2GAANFATC1GSK3BDYRK1A | |
| SCHEMBL275572 | 0.71 | KDM4E (0.63) | IMPDH2KDM4ELMNACYP1A2CYP3A4 | |
| SCHEMBL12441263 | 0.71 | IMPDH2 (0.48) | IMPDH2KDM4ELMNACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2499129-A1 | QUINOLINE AND QUINOXALINE DERIVATIVES AS KINASE INHIBITORS | UCB Pharma, S.A. (BE) | 2012-09-19 | — | — | EP | disclosed |
| WO-2011058108-A1 | QUINOLINE AND QUINOXALINE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2011-05-19 | — | — | WO | disclosed |