Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3249035 | 0.88 | KCNH2 (0.48) | KCNH2SMN1; SMN2MAPTNPC1TP53 | |
| SCHEMBL1147478 | 0.86 | KCNH2 (0.54) | KCNH2KDM4EL3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL1148050 | 0.85 | KCNH2 (0.52) | KCNH2KDM4EL3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL1147525 | 0.83 | KCNH2 (0.53) | KCNH2KDM4EL3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL1147476 | 0.82 | KCNH2 (0.52) | KCNH2KDM4EL3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL1147947 | 0.82 | KCNH2 (0.52) | KCNH2KDM4EL3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL1147536 | 0.80 | KCNH2 (0.53) | KCNH2KDM4EL3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL3250680 | 0.79 | KCNH2 (0.41) | KCNH2 | |
| SCHEMBL3250684 | 0.79 | KCNH2 (0.41) | KCNH2 | |
| SCHEMBL3376809 | 0.79 | KCNH2 (0.41) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7888359-B2 | Cyclohexyl or piperidinyl carboxamide antibiotic derivatives | ACTELION PHARMACEUTICAL LTD. (CH) | 2011-02-15 | — | — | US | claimed |
| US-7888359-B2 | Cyclohexyl or piperidinyl carboxamide antibiotic derivatives | ACTELION PHARMACEUTICAL LTD. (CH) | 2011-02-15 | — | — | US | disclosed |