Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1147993 | 0.88 | KDM4E (0.45) | KCNH2KDM4EL3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL3255856 | 0.88 | KCNH2 (0.47) | KCNH2SMN1; SMN2SLC2A1MAPTNPC1 | |
| SCHEMBL1147525 | 0.88 | KCNH2 (0.53) | KCNH2KDM4EL3MBTL1SMN1; SMN2SLC2A1 | |
| SCHEMBL1148151 | 0.88 | KDM4E (0.45) | KCNH2KDM4EL3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL1147433 | 0.85 | KCNH2 (0.53) | KCNH2KDM4EL3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL1147924 | 0.82 | KDM4E (0.46) | KCNH2KDM4EL3MBTL1SMN1; SMN2SLC2A1 | |
| SCHEMBL1147536 | 0.81 | KCNH2 (0.53) | KCNH2KDM4EL3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL1147478 | 0.80 | KCNH2 (0.54) | KCNH2KDM4EL3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL1147955 | 0.80 | TRPV1 (0.43) | KCNH2 | |
| SCHEMBL3249797 | 0.79 | KCNH2 (0.43) | KCNH2SLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7888359-B2 | Cyclohexyl or piperidinyl carboxamide antibiotic derivatives | ACTELION PHARMACEUTICAL LTD. (CH) | 2011-02-15 | — | — | US | claimed |
| US-7888359-B2 | Cyclohexyl or piperidinyl carboxamide antibiotic derivatives | ACTELION PHARMACEUTICAL LTD. (CH) | 2011-02-15 | — | — | US | disclosed |