Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | SLC6A19 | Q695T7 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.35 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1147434 | 1.00 | ALDH1A1 (0.41) | ALDH1A1CTSBCTSSCTSKSLC6A19 | |
| SCHEMBL490921 | 0.88 | NPC1 (0.42) | ALDH1A1CTSSCTSKNR1H4AAK1 | |
| SCHEMBL1147485 | 0.84 | AAK1 (0.40) | ALDH1A1CTSBCTSSCTSKNR1H4 | |
| SCHEMBL1148192 | 0.78 | IKBKB (0.46) | — | |
| SCHEMBL490801 | 0.76 | AAK1 (0.44) | ALDH1A1NR1H4AAK1BACE1KMT2A | |
| SCHEMBL490391 | 0.76 | AAK1 (0.44) | ALDH1A1NR1H4AAK1BACE1KMT2A | |
| SCHEMBL490479 | 0.76 | AAK1 (0.39) | NR1H4AAK1KMT2AL3MBTL1USP30 | |
| SCHEMBL490602 | 0.74 | CHEK1 (0.47) | KMT2A | |
| SCHEMBL375738 | 0.74 | EPHX1 (0.38) | ALDH1A1CTSSCTSKMAPTKMT2A | |
| SCHEMBL1147982 | 0.74 | CACNA1B (0.53) | ALDH1A1CTSBCTSSCTSKSLC6A19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110039920-A1 | INHIBITORS OF IKK-BETA SERINE-THERONINE PROTEIN KINASE | CHROMA THERAPEUTICS LTD. (GB) | 2011-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110039920-A1 | INHIBITORS OF IKK-BETA SERINE-THERONINE PROTEIN KINASE | CSNK1E, PACSIN2, CHUK | ALDH1A1 4456/4885CTSB 974/4885CTSS 1123/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.