Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 2/20 | 0.53 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.53 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.53 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.53 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.53 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.53 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.53 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.53 |
| ▸ | APP | P05067 | 2/20 | 0.53 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | PRNP | P04156 | 1/20 | 0.53 |
| ▸ | NQO2 | P16083 | 1/20 | 0.53 |
| ▸ | MTOR | P42345 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1147605 | 1.00 | CHRM2 (0.53) | CHRM2CHRM4CHRM5ADRA2ACHRM1 | |
| SCHEMBL1147504 | 0.99 | NR4A2 (0.54) | CHRM2CHRM4CHRM5ADRA2ACHRM1 | |
| SCHEMBL1146976 | 0.95 | NR4A2 (0.55) | CHRM2CHRM4CHRM5ADRA2ACHRM1 | |
| SCHEMBL1147338 | 0.93 | NR4A2 (0.55) | CHRM2CHRM4CHRM5ADRA2ACHRM1 | |
| SCHEMBL1147526 | 0.81 | KDM4E (0.46) | CHRM2CHRM4CHRM5ADRA2ACHRM1 | |
| SCHEMBL1147384 | 0.81 | KDM4E (0.46) | CHRM2CHRM4CHRM5ADRA2ACHRM1 | |
| SCHEMBL3454549 | 0.81 | KCNH2 (0.60) | CHRM2CHRM4CHRM5ADRA2ACHRM1 | |
| SCHEMBL11139089 | 0.81 | CHKA (0.53) | CHRM2CHRM4CHRM5ADRA2ACHRM1 | |
| SCHEMBL1147575 | 0.80 | KDM4E (0.47) | CHRM2CHRM4CHRM5ADRA2ACHRM1 | |
| SCHEMBL1550998 | 0.77 | KDM4E (0.58) | CHRM2CHRM4CHRM5ADRA2ACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110045100-A1 | Antimalarial Quinolines and Methods of Use Thereof | GEORGETOWN UNIVERSITY (US) | 2011-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110045100-A1 | Antimalarial Quinolines and Methods of Use Thereof | NQO2, QTRT1, QTRT2 | CHRM2 2264/4885CHRM4 2013/4885CHRM5 1445/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.