Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 14/20 | 0.40 |
| ▸ | CHRM2 known ✓ | P08172 | 10/20 | 0.40 |
| ▸ | CHRM1 known ✓ | P11229 | 3/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.39 |
| ▸ | HRH1 | P35367 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11469034 | 0.89 | CHRM3 (0.43) | CHRM3CHRM2KCNH2CHRM1CHRM4 | |
| Hydrochloric Acid SCHEMBL11478184 | 0.87 | CHRM3 (0.41) | CHRM3CHRM2KCNH2CHRM1CHRM4 | |
| Bromide SCHEMBL11476964 | 0.85 | CHRM3 (0.44) | CHRM3CHRM2KCNH2CHRM1CHRM4 | |
| Bromide SCHEMBL11466593 | 0.85 | CHRM3 (0.44) | CHRM3CHRM2KCNH2CHRM1CHRM4 | |
| Bromide SCHEMBL11473155 | 0.85 | CHRM3 (0.44) | CHRM3CHRM2KCNH2CHRM1CHRM4 | |
| Hydrochloric Acid SCHEMBL11469365 | 0.84 | CHRM3 (0.40) | CHRM3CHRM2KCNH2CHRM1CHRM4 | |
| Hydrochloric Acid SCHEMBL11468131 | 0.82 | CHRM3 (0.34) | CHRM3CHRM2KCNH2CHRM1CHRM4 | |
| Hydrochloric Acid SCHEMBL11469933 | 0.80 | CHRM3 (0.69) | CHRM3CHRM2KCNH2CHRM1CHRM4 | |
| Bromide SCHEMBL11470303 | 0.78 | CHRM3 (0.71) | CHRM3CHRM2KCNH2CHRM1CHRM4 | |
| Hydrochloric Acid SCHEMBL11468025 | 0.75 | CHRM3 (0.44) | CHRM3CHRM2KCNH2CHRM1CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4208423-A | Anticholinergic bronchodilators | SYNTEX INC. (US) | 1980-06-17 | — | — | US | disclosed |