Perlapine

Perlapine

SCHEMBL114768

CN1CCN(C2=Nc3ccccc3Cc3ccccc32)CC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
HRH4 Q9H3N8 4/20 1.00
MAPK1 P28482 1/20 0.73
DRD2 P14416 3/20 0.61
DRD4 P21917 3/20 0.61
HRH1 P35367 2/20 0.60
HTR2A P28223 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Perlapine SCHEMBL29397855 1.00 HRH4 (1.00) HRH4MAPK1DRD2DRD4HRH1
SCHEMBL25462854 0.85 MAPK1 (0.73) HRH4MAPK1DRD2DRD4HRH1
SCHEMBL13409920 0.85 MAPK1 (0.73) HRH4MAPK1DRD2DRD4HRH1
Fluperlapine SCHEMBL142558 0.85 MAPK1 (1.00) HRH4MAPK1DRD2DRD4HRH1
Fluperlapine SCHEMBL30274851 0.85 MAPK1 (1.00) HRH4MAPK1DRD2DRD4HRH1
SCHEMBL141985 0.83 HRH4 (0.71) HRH4MAPK1DRD2DRD4HRH1
SCHEMBL7406099 0.82 HRH4 (0.70) HRH4MAPK1DRD2DRD4HRH1
SCHEMBL5946355 0.80 HRH1 (0.69) HRH4MAPK1DRD2DRD4HRH1
SCHEMBL11855700 0.80 HRH4 (0.66) HRH4MAPK1DRD2DRD4HRH1
SCHEMBL11566269 0.79 HRH4 (0.65) HRH4MAPK1DRD2DRD4HRH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 3289 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3507371-B1 COMPOSITIONS FOR TREATING DISEASES AND DISORDERS OF THE NERVOUS SYSTEM UNIV RUTGERS (US) 2026-01-28 EP claimed
EP-4622640-A1 COMPOSITIONS AND METHODS FOR MODULATING SLEEP AND USES THEREOF Brightseed, Inc. (US) 2025-10-01 EP claimed
US-20250295611-A1 METHODS OF TREATING 5HT2A RECEPTOR-MEDIATED CONDITIONS TESSELLATE THERAPEUTICS INC (US) 2025-09-25 US claimed
US-20250281451-A1 COMPOSITIONS AND METHODS FOR MODULATING SLEEP AND USES THEREOF BRIGHTSEED, INC. 2025-09-11 US claimed
WO-2024248583-A1 COMPOSITION FOR MIMICKING ACUPUNCTURE TREATMENT 한국과학기술연구원 2024-12-05 WO claimed
US-20240325452-A1 METHODS AND COMPOSITIONS FOR DREADD-ACTIVATABLE CELLS FOR NEURAL REPAIR DREXEL UNIVERSITY 2024-10-03 US claimed
US-20240238250-A1 METHOD OF USING PIROMELATINE FOR TREATING PARASOMNIAS ASSOCIATED WITH LOSS OF REM SLEEP ATONIA NEURIM PHARMACEUTICALS (1991) LTD. (IL) 2024-07-18 US claimed
WO-2024150170-A1 PIROMELATINE FOR TREATING PARASOMNIAS ASSOCIATED WITH LOSS OF REM SLEEP ATONIA NEURIM PHARMACEUTICALS (1991) LTD. (IL) 2024-07-18 WO claimed
WO-2024113093-A1 METHOD FOR REGULATING REWARD DEVALUATION CHINESE INSTITUTE FOR BRAIN RESEARCH, BEIJING (CIBR) (CN) 2024-06-06 WO claimed
WO-2024112947-A1 COMPOSITIONS AND METHODS FOR MODULATING SLEEP AND USES THEREOF BRIGHTSEED, INC. (US) 2024-05-30 WO claimed
EP-1073470-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2001-02-07 EP claimed
JP-2000511885-A 2000-09-12 JP claimed
WO-2000048636-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2000-08-24 WO claimed
EP-0900086-A4 ENHANCEMENT OF SLEEP WITH A GROWTH HORMONE SECRETAGOGUE MERCK & CO INC (US) 2000-01-12 EP claimed
EP-0900086-A1 ENHANCEMENT OF SLEEP WITH A GROWTH HORMONE SECRETAGOGUE Merck & Co., Inc. (US) 1999-03-10 EP claimed
US-5811547-A Method for inducing crystalline state transition in medicinal substance NIPPON SHINYAJU CO., LTD. (JP) 1998-09-22 US claimed
WO-1997041879-A1 ENHANCEMENT OF SLEEP WITH A GROWTH HORMONE SECRETAGOGUE MERCK & CO., INC. (US) 1997-11-13 WO claimed
EP-0174342-B1 BRAIN-SPECIFIC ANALOGUES OF CENTRALLY ACTING AMINES UNIVERSITY OF FLORIDA (US) 1989-12-20 EP claimed
EP-0174342-A1 BRAIN-SPECIFIC ANALOGUES OF CENTRALLY ACTING AMINES. UNIV FLORIDA (US) 1986-03-19 EP claimed
WO-1985003937-A1 BRAIN-SPECIFIC ANALOGUES OF CENTRALLY ACTING AMINES UNIVERSITY OF FLORIDA (US) 1985-09-12 WO claimed