Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | DRD2 | P14416 | 6/20 | 0.46 |
| ▸ | DRD4 | P21917 | 4/20 | 0.46 |
| ▸ | DRD1 | P21728 | 4/20 | 0.44 |
| ▸ | DRD3 | P35462 | 4/20 | 0.44 |
| ▸ | DRD5 | P21918 | 3/20 | 0.44 |
| ▸ | HTR2A | P28223 | 3/20 | 0.43 |
| ▸ | HRH1 | P35367 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11877889 | 0.86 | HRH4 (0.49) | HRH4MAPK1DRD2DRD4DRD1 | |
| SCHEMBL11865045 | 0.82 | HRH4 (0.50) | HRH4MAPK1DRD2DRD4DRD1 | |
| SCHEMBL7406099 | 0.81 | HRH4 (0.70) | HRH4MAPK1DRD2DRD4DRD1 | |
| Perlapine SCHEMBL114768 | 0.80 | HRH4 (1.00) | HRH4MAPK1DRD2DRD4HTR2A | |
| Perlapine SCHEMBL29397855 | 0.80 | HRH4 (1.00) | HRH4MAPK1DRD2DRD4HTR2A | |
| SCHEMBL11535917 | 0.76 | DRD2 (0.67) | HRH4MAPK1DRD2DRD4DRD1 | |
| SCHEMBL11872463 | 0.73 | HRH4 (0.38) | HRH4DRD2DRD4DRD1DRD3 | |
| SCHEMBL7420397 | 0.73 | NOS2 (0.49) | HRH4DRD2DRD4DRD1DRD3 | |
| SCHEMBL12559393 | 0.72 | HRH4 (0.62) | HRH4MAPK1DRD2DRD4DRD1 | |
| SCHEMBL11566269 | 0.72 | HRH4 (0.65) | HRH4MAPK1DRD2DRD4DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3959282-A | ANTIPSYCHOLICS, SOPORIFICES | SANDOZ LTD. (CH) | 1976-05-25 | — | — | US | claimed |
| US-3959282-A | ANTIPSYCHOLICS, SOPORIFICES | SANDOZ LTD. (CH) | 1976-05-25 | — | — | US | disclosed |