Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 5/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 11/20 | 0.39 |
| ▸ | AURKA | O14965 | 9/20 | 0.39 |
| ▸ | PPARA | Q07869 | 2/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16156479 | 0.84 | CHRNA7 (0.39) | CHRNA7AURKBAURKAPPARAPPARG | |
| SCHEMBL1147631 | 0.83 | MEN1 (0.33) | CHRNA7PPARAPPARGPTGES | |
| SCHEMBL1148104 | 0.82 | CHRNA7 (0.47) | CHRNA7AURKBAURKASRCGSK3B | |
| SCHEMBL1147568 | 0.82 | PTGES (0.35) | PPARAPPARGPTGES | |
| SCHEMBL1148030 | 0.82 | AURKB (0.42) | CHRNA7AURKBAURKASRCGSK3B | |
| SCHEMBL1148241 | 0.81 | AURKA (0.51) | AURKBAURKASRCGSK3B | |
| SCHEMBL1148052 | 0.81 | AURKB (0.44) | CHRNA7AURKBAURKAPPARAPPARG | |
| SCHEMBL1148028 | 0.81 | AURKB (0.43) | AURKBAURKASRC | |
| SCHEMBL1148025 | 0.81 | AURKB (0.43) | AURKBAURKASRC | |
| SCHEMBL3034270 | 0.81 | AURKB (0.43) | CHRNA7AURKBAURKAPPARAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140303137-A1 | AMINOPYRIMIDINES USEFUL AS KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED | 2014-10-09 | — | — | US | disclosed |
| US-20140303137-A1 | AMINOPYRIMIDINES USEFUL AS KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED | 2014-10-09 | — | — | US | disclosed |
| EP-2152696-B1 | AMINOPYRIMIDINES USEFUL AS KINASE INHIBITORS | VERTEX PHARMA (US) | 2014-09-24 | — | — | EP | disclosed |
| EP-2152696-B1 | AMINOPYRIMIDINES USEFUL AS KINASE INHIBITORS | VERTEX PHARMA (US) | 2014-09-24 | — | — | EP | disclosed |
| US-20140037754-A1 | AMINOPYRIMIDINES USEFUL AS KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-02-06 | — | — | US | disclosed |
| US-20140037754-A1 | AMINOPYRIMIDINES USEFUL AS KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-02-06 | — | — | US | disclosed |
| US-8383633-B2 | Aminopyrimidines useful as kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-02-26 | — | — | US | disclosed |
| US-8383633-B2 | Aminopyrimidines useful as kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-02-26 | — | — | US | disclosed |
| US-8383633-B2 | Aminopyrimidines useful as kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-02-26 | — | — | US | disclosed |
| US-20110046104-A1 | AMINOPYRIMIDINES USEFUL AS KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-02-24 | — | — | US | disclosed |
| US-20110046104-A1 | AMINOPYRIMIDINES USEFUL AS KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-02-24 | — | — | US | disclosed |
| US-20100215772-A1 | AMINOPYRIMIDINES USEFUL AS KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-08-26 | — | — | US | disclosed |
| US-20100215772-A1 | AMINOPYRIMIDINES USEFUL AS KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-08-26 | — | — | US | disclosed |
| US-20100215772-A1 | AMINOPYRIMIDINES USEFUL AS KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-08-26 | — | — | US | disclosed |
| EP-2155730-A2 | AMINOPYRIMIDINES USEFUL AS KINASE INHIBITORS | Vertex Pharmaceuticals Incorporated (US) | 2010-02-24 | — | — | EP | disclosed |
| EP-2152696-A1 | AMINOPYRIMIDINES USEFUL AS KINASE INHIBITORS | Vertex Pharmaceuticals Incorporated (US) | 2010-02-17 | — | — | EP | disclosed |
| WO-2008137621-A1 | AMINOPYRIMIDINES USEFUL AS KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-11-13 | — | — | WO | disclosed |
| WO-2008137622-A2 | AMINOPYRIMIDINES USEFUL AS KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-11-13 | — | — | WO | disclosed |
| WO-2008137622-A2 | AMINOPYRIMIDINES USEFUL AS KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-11-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046104-A1 | AMINOPYRIMIDINES USEFUL AS KINASE INHIBITORS | AURKC, AURKA, AURKB | CHRNA7 4762/4885AURKB 3/4885AURKA 2/4885 |
| US-20140037754-A1 | AMINOPYRIMIDINES USEFUL AS KINASE INHIBITORS | AURKC, AURKA, AURKB | CHRNA7 4762/4885AURKB 3/4885AURKA 2/4885 |
| US-20140303137-A1 | AMINOPYRIMIDINES USEFUL AS KINASE INHIBITORS | AURKC, AURKA, AURKB | CHRNA7 4762/4885AURKB 3/4885AURKA 2/4885 |
| US-20100215772-A1 | AMINOPYRIMIDINES USEFUL AS KINASE INHIBITORS | AURKC, AURKA, AURKB | CHRNA7 4762/4885AURKB 3/4885AURKA 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.