Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1147993 | 1.00 | KDM4E (0.45) | KDM4EL3MBTL1SMN1; SMN2KCNH2ALDH1A1 | |
| SCHEMBL3252259 | 0.88 | MAPT (0.41) | KDM4ESMN1; SMN2ALDH1A1MAPTPOLB | |
| SCHEMBL1148050 | 0.88 | KCNH2 (0.52) | KDM4EL3MBTL1SMN1; SMN2KCNH2ALDH1A1 | |
| SCHEMBL1147755 | 0.80 | TRPV1 (0.45) | KDM4EALDH1A1MAPTMEN1HTT | |
| SCHEMBL3245683 | 0.79 | PDE4B (0.36) | KDM4EKMT2AGAA | |
| SCHEMBL3243332 | 0.79 | PDE4B (0.36) | KDM4EKMT2AGAA | |
| SCHEMBL3243324 | 0.79 | PDE4B (0.36) | KDM4EKMT2AGAA | |
| SCHEMBL3245687 | 0.79 | PDE4B (0.36) | KDM4EKMT2AGAA | |
| SCHEMBL1147467 | 0.77 | KDM4E (0.42) | KDM4EL3MBTL1SMN1; SMN2KCNH2ALDH1A1 | |
| SCHEMBL3255856 | 0.77 | KCNH2 (0.47) | SMN1; SMN2KCNH2ALDH1A1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7888359-B2 | Cyclohexyl or piperidinyl carboxamide antibiotic derivatives | ACTELION PHARMACEUTICAL LTD. (CH) | 2011-02-15 | — | — | US | disclosed |