Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 3/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | TDO2 | P48775 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.41 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1996001 | 0.88 | KDM4E (0.51) | KDM4EBACE1KCNH2NCOA1NCOA3 | |
| SCHEMBL7112634 | 0.81 | KDM4E (0.53) | KDM4EHRH3 | |
| SCHEMBL11493291 | 0.81 | KDM4E (0.48) | KDM4ENPC1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL7571712 | 0.81 | PTPN1 (0.44) | KDM4ENPC1TP53NFKB1RAB9A | |
| SCHEMBL11500095 | 0.80 | KDM4E (0.40) | KDM4EBACE1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL18380643 | 0.80 | KDM4E (0.61) | KDM4EHRH3 | |
| SCHEMBL29616919 | 0.80 | KDM4E (0.61) | KDM4EHRH3 | |
| SCHEMBL7824728 | 0.79 | NPC1 (0.47) | KDM4ENPC1RAB9A | |
| SCHEMBL10835648 | 0.79 | KDM4E (0.50) | KDM4EHRH3 | |
| SCHEMBL8443277 | 0.78 | CYP1A1 (0.56) | KDM4EBACE1KCNH2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4220778-A | ANTIARRHYTHMIC, ANTIMICROBIAL AND CENTRAL NERVOUS SYSTEM ACTIVITY | G. D. SEARLE & CO. (US) | 1980-09-02 | — | — | US | disclosed |