Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 3/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.38 |
| ▸ | C5 | P01031 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.37 |
| ▸ | APP | P05067 | 2/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.36 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11488823 | 0.93 | PTGS1 (0.56) | PTGS1CHRM1PTGS2MEN1ABCC4 | |
| Hydrochloric Acid SCHEMBL11493900 | 0.92 | PTGS1 (0.55) | PTGS1CHRM1PTGS2MEN1ABCC4 | |
| SCHEMBL11485527 | 0.84 | PTGS1 (0.51) | PTGS1CHRM1PTGS2MEN1MAPT | |
| SCHEMBL11493481 | 0.84 | CHRM1 (0.45) | PTGS1CHRM1EGLN1CYP46A1 | |
| SCHEMBL11487077 | 0.82 | CHRM1 (0.43) | PTGS1CHRM1APPEGLN1CYP46A1 | |
| SCHEMBL11486961 | 0.81 | PTGS1 (0.42) | PTGS1CHRM1PTGS2MEN1MAPT | |
| SCHEMBL11487149 | 0.81 | PTGS1 (0.57) | PTGS1CHRM1PTGS2MEN1ABCC4 | |
| SCHEMBL11493818 | 0.81 | PTGS1 (0.54) | PTGS1CHRM1PTGS2MEN1ABCC4 | |
| SCHEMBL11493771 | 0.81 | PTGS1 (0.42) | PTGS1CHRM1PTGS2MEN1MAPT | |
| SCHEMBL11492267 | 0.81 | CHRM1 (0.42) | PTGS1CHRM1EGLN1CYP46A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4239901-A | ANALGESICS, ANTIPYRETICS, ANTIINFLAMMATORY AGENTS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1980-12-16 | — | — | US | disclosed |