SCHEMBL11488342

SCHEMBL11488342

Nc1ccc(C(Cl)CS(=O)(=O)CC(Cl)c2ccc(N)cc2)cc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRIA4 P48058 1/20 0.40
TSHR P16473 3/20 0.38
CYP3A4 P08684 2/20 0.38
LMNA P02545 1/20 0.38
MPO P05164 1/20 0.38
CYP2C9 P11712 1/20 0.38
HTR6 P50406 1/20 0.38
CA1 P00915 7/20 0.38
CA2 P00918 7/20 0.38
CA12 O43570 6/20 0.38
CA9 Q16790 6/20 0.38
CA14 Q9ULX7 2/20 0.37
USP2 O75604 1/20 0.37
CA4 P22748 1/20 0.37
CA6 P23280 1/20 0.37
CA5A P35218 1/20 0.37
CA7 P43166 1/20 0.37
CA13 Q8N1Q1 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
AGO2 Q9UKV8 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8494043 0.75 CYP19A1 (0.41) GRIA4TSHRCYP3A4LMNAMPO
SCHEMBL9790496 0.74 ALDH1A1 (0.51) LMNACA1CA2CA12CA9
SCHEMBL4082820 0.73 TSHR (0.43) GRIA4TSHRCYP3A4LMNAMPO
Hydrogen Sulfide SCHEMBL28207580 0.73 CYP19A1 (0.40) GRIA4TSHRCYP3A4LMNAMPO
SCHEMBL11426670 0.72 SLC6A2 (0.41) CYP3A4LMNAALDH1A1
Sulfuric Acid SCHEMBL27525453 0.72 TSHR (0.42) GRIA4TSHRCYP3A4LMNAMPO
SCHEMBL11488424 0.71 GRIA4 (0.41) GRIA4TSHRCYP3A4LMNAMPO
SCHEMBL11478931 0.68 GAA (0.39) GRIA4TSHRCYP3A4LMNAMPO
SCHEMBL11309027 0.67 GRIA4 (0.56) GRIA4TSHRCYP3A4LMNAMPO
SCHEMBL1275322 0.67 GRIA4 (0.56) GRIA4TSHRCYP3A4LMNAMPO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4204056-A Process and intermediates for preparing fiber-reactive phthalocyanine dyes CASSELLA AKTIENGESELLSCHAFT (DE) 1980-05-20 US disclosed
US-4191686-A FROM SULFONYL HALIDE SUBSTITUTED PARENT BY AMIDATION WITH AROMATIC DIAMINE, DIAZOTIZING, COUPLING TO KETO SUCCINIC ESTER, CYCLIZING, COUPLING TO REACTIVE MOIETY CASSELLA AKTIENGESELLSCHAFT (DE) 1980-03-04 US disclosed