Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 10/20 | 0.58 |
| ▸ | LCK | P06239 | 5/20 | 0.58 |
| ▸ | KDR | P35968 | 9/20 | 0.57 |
| ▸ | JAK3 | P52333 | 2/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | SRPK2 | P78362 | 1/20 | 0.48 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.48 |
| ▸ | SRPK3 | Q9UPE1 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1078914 | 0.99 | TEK (0.57) | TEKLCKKDRJAK3MAPK14 | |
| SCHEMBL1078646 | 0.94 | LCK (0.51) | TEKLCKKDRJAK3MAPK14 | |
| SCHEMBL1078076 | 0.93 | ALDH1A1 (0.51) | TEKLCKKDRJAK3MAPK14 | |
| SCHEMBL1080145 | 0.88 | KDR (0.56) | TEKLCKKDRJAK3MAPK14 | |
| SCHEMBL1149173 | 0.88 | KDR (0.54) | TEKLCKKDRJAK3MAPK14 | |
| SCHEMBL1077386 | 0.87 | KDR (0.53) | TEKLCKKDRJAK3MAPK14 | |
| SCHEMBL1077490 | 0.83 | LCK (0.60) | TEKLCKKDRJAK3MAPK14 | |
| SCHEMBL1083503 | 0.82 | LCK (0.48) | TEKLCKKDRJAK3MAPK14 | |
| SCHEMBL1078661 | 0.82 | LCK (0.47) | TEKLCKKDRJAK3MAPK14 | |
| SCHEMBL1075954 | 0.81 | BRAF (0.55) | BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110039845-A1 | 2-AMINOQUINAZOLINE DERIVATIVE | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2011-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110039845-A1 | 2-AMINOQUINAZOLINE DERIVATIVE | H1-2, H1-3, H1-0 | TEK 2366/4885LCK 3187/4885KDR 896/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.