Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.61 |
| ▸ | MAPT | P10636 | 4/20 | 0.61 |
| ▸ | TSHR | P16473 | 4/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.54 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.54 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | HTR6 | P50406 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11493601 | 0.86 | MAPT (0.52) | CYP3A4MAPTTSHRCYP2C19CYP1A2 | |
| SCHEMBL31034424 | 0.83 | HPGD (0.58) | CYP3A4MAPTTSHRCYP2C19CYP1A2 | |
| SCHEMBL18919603 | 0.79 | TSHR (0.58) | CYP3A4MAPTTSHRCYP2C19CYP1A2 | |
| SCHEMBL11495550 | 0.77 | CYP3A4 (0.52) | CYP3A4MAPTTSHRCYP2C19MEN1 | |
| SCHEMBL14540350 | 0.77 | CYP3A4 (0.64) | CYP3A4MAPTTSHRCYP2C19MEN1 | |
| 2-Methyl Gramine SCHEMBL2519973 | 0.76 | MAPT (1.00) | CYP3A4MAPTTSHRCYP2C19CYP1A2 | |
| SCHEMBL8804026 | 0.76 | MTNR1A (0.59) | CYP3A4MAPTTSHRCYP2C19CYP1A2 | |
| SCHEMBL11495830 | 0.76 | HTR2A (0.71) | CYP3A4MAPTCYP2C19CYP1A2HPGD | |
| SCHEMBL2087168 | 0.75 | HPGD (0.61) | CYP3A4MAPTTSHRCYP2C19CYP1A2 | |
| SCHEMBL28543275 | 0.75 | AHR (0.52) | CYP3A4MAPTTSHRCYP2C19CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4217357-A | Inhibition of thromboxane synthetase with 3-(imidazol-1-ylalkyl)indoles | PFIZER INC. (US) | 1980-08-12 | — | — | US | disclosed |