Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.79 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.79 |
| ▸ | ABL1 | P00519 | 2/20 | 0.78 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.70 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.61 |
| ▸ | MPL | P40238 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | PARP1 | P09874 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12249057 | 0.89 | LMNA (0.82) | LMNAALDH1A1MAPK1ABL1SMN1; SMN2 | |
| SCHEMBL11469127 | 0.89 | LMNA (1.00) | LMNAALDH1A1MAPK1ABL1SMN1; SMN2 | |
| SCHEMBL25287793 | 0.89 | LMNA (0.90) | LMNAALDH1A1MAPK1ABL1SMN1; SMN2 | |
| SCHEMBL5698578 | 0.88 | LMNA (1.00) | LMNAALDH1A1MAPK1ABL1SMN1; SMN2 | |
| SCHEMBL12248945 | 0.88 | LMNA (0.80) | LMNAALDH1A1MAPK1ABL1SMN1; SMN2 | |
| SCHEMBL6154942 | 0.87 | ABL1 (1.00) | LMNAALDH1A1MAPK1ABL1SMN1; SMN2 | |
| SCHEMBL30263326 | 0.85 | LMNA (0.80) | LMNAALDH1A1MAPK1ABL1SMN1; SMN2 | |
| SCHEMBL12301022 | 0.85 | LMNA (0.75) | LMNAALDH1A1MAPK1ABL1SMN1; SMN2 | |
| SCHEMBL2304197 | 0.82 | NPC1 (0.66) | LMNAALDH1A1MAPK1ABL1KMT2A | |
| SCHEMBL6249035 | 0.81 | SCD (0.74) | LMNAALDH1A1KMT2AMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4225610-A | TREATMENT OF RHEUMATOID ARTHRITIS | PIERRE FABRE, S.A. (FR) | 1980-09-30 | — | — | US | disclosed |