Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KCNK3 | O14649 | 4/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | STS | P08842 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.32 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11508354 | 0.89 | HTR2C (0.36) | MEN1KMT2AHTTTRPV1STS | |
| SCHEMBL11508068 | 0.87 | AKR1C3 (0.40) | MEN1KMT2AKCNK3AKR1C3ALDH1A1 | |
| SCHEMBL11454237 | 0.79 | KMT2A (0.36) | MEN1KMT2AHTTKCNK3ALDH1A1 | |
| SCHEMBL11508869 | 0.76 | CYP1A2 (0.39) | MEN1KMT2AHTTTRPV1ALDH1A1 | |
| SCHEMBL11507932 | 0.74 | THRB (0.43) | MEN1KMT2AHTTALDH1A1LMNA | |
| SCHEMBL11510100 | 0.74 | CYP1A2 (0.38) | MEN1KMT2AHTTTRPV1ALDH1A1 | |
| SCHEMBL11508450 | 0.73 | CYP1A2 (0.37) | MEN1KMT2AHTTTRPV1ALDH1A1 | |
| SCHEMBL11508260 | 0.69 | S1PR1 (0.39) | MEN1KMT2AHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL11509314 | 0.67 | KCNK3 (0.40) | HTTKCNK3ALDH1A1MAPT | |
| SCHEMBL11459799 | 0.66 | MEN1 (0.32) | MEN1KMT2AHTTALDH1A1HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4160098-A | DIURETICS, SALURETICS, HYPOTENSIVE AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1979-07-03 | — | — | US | disclosed |
| US-4122281-A | DIURETIC, SALURETIC, ANTIHYPERTENSIVE | BAYER AKTIENGESELLSCHAFT (DE) | 1978-10-24 | — | — | US | disclosed |
| US-4122280-A | DIURETIC, SALURETIC, ANTIHYPERTENSIVE | BAYER AKTIENGESELLSCHAFT (DE) | 1978-10-24 | — | — | US | disclosed |
| US-4122279-A | DIURETIC, SALURETIC, ANTIHYPERTENSIVE | BAYER AKTIENGESELLSCHAFT (DE) | 1978-10-24 | — | — | US | disclosed |
| US-4096152-A | DIURETICS, SALURETICS, HYPOTENSIVE | BAYER AKTIENGESELLSCHAFT (DT) | 1978-06-20 | — | — | US | disclosed |
| US-4069334-A | DIURETICS, HYPOTENSIVES | BAYER AKTIENGESELLSCHAFT (DT) | 1978-01-17 | — | — | US | disclosed |
| US-4002641-A | DIURETICS, SALURETICS, HYPOTENSIVES | BAYER AKTIENGESELLSCHAFT (DT) | 1977-01-11 | — | — | US | disclosed |