Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 4/20 | 0.58 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.46 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | SGMS2 | Q8NHU3 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8072945 | 0.87 | PTGER1 (0.52) | FOLH1PTGER1KDM4EPOLBFFAR4 | |
| SCHEMBL8658870 | 0.82 | MAOB (0.55) | FOLH1PTGER1L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL5460706 | 0.82 | PTGER1 (0.65) | FOLH1PTGER1CYP2C9 | |
| SCHEMBL2394315 | 0.82 | SMPD1 (0.59) | KDM4EALDH1A1LMNANPC1HTT | |
| SCHEMBL2392671 | 0.82 | NPC1 (0.60) | KDM4ENPC1CYP2C9SMN1; SMN2 | |
| SCHEMBL21327456 | 0.81 | LRRK2 (0.57) | FOLH1PTGER1L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL341109 | 0.80 | SGMS2 (0.62) | FOLH1PTGER1L3MBTL1ALDH1A1SGMS2 | |
| SCHEMBL11508209 | 0.79 | FOLH1 (0.74) | FOLH1PTGER1L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL8076364 | 0.78 | GLRA1 (0.52) | FOLH1PTGER1KDM4EALDH1A1GLRA1 | |
| SCHEMBL2469286 | 0.77 | MRGPRX4 (0.52) | FOLH1PTGER1KDM4EALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4160781-A | 4-Benzyloxy-3-(chlorocarbonyl)-phenylacetyl chloride | AMERICAN HOECHST CORPORATION (US) | 1979-07-10 | — | — | US | claimed |
| US-4175209-A | Preparation of 6,11-dihydro-11-oxodibenz[b,e]-oxepin-2-acetic acid and precursors therefor | AMERICAN HOECHST CORPORATION (US) | 1979-11-20 | — | — | US | disclosed |
| US-4160781-A | 4-Benzyloxy-3-(chlorocarbonyl)-phenylacetyl chloride | AMERICAN HOECHST CORPORATION (US) | 1979-07-10 | — | — | US | disclosed |
| US-4160781-A | 4-Benzyloxy-3-(chlorocarbonyl)-phenylacetyl chloride | AMERICAN HOECHST CORPORATION (US) | 1979-07-10 | — | — | US | disclosed |
| US-4153790-A | 4-Benzyloxy-3-(benzyloxy carbonyl)phenylthioacetmorpholide | AMERICAN HOECHST CORPORATION (US) | 1979-05-08 | — | — | US | disclosed |
| US-4153791-A | 3-Carboxy-4 hydroxyphenylthioacetmorpholide | AMERICAN HOECHST CORPORATION (US) | 1979-05-08 | — | — | US | disclosed |
| US-4118401-A | Preparation of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid and precursors therefor | AMERICAN HOECHST CORPORATION (US) | 1978-10-03 | — | — | US | disclosed |