SGMS2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL683595	0.53	11/20
SCHEMBL477534	0.49	10/20
SCHEMBL168577	0.51	9/20
SCHEMBL488883	0.56	8/20
SCHEMBL167926	0.48	7/20
SCHEMBL974381	0.72	6/20
SCHEMBL975589	0.57	5/20
SCHEMBL712291	0.57	5/20
SCHEMBL316291	0.53	5/20
SCHEMBL532963	0.52	5/20
SCHEMBL720659	0.50	5/20
SCHEMBL219488	0.42	5/20
SCHEMBL875474	1.00	4/20
SCHEMBL341109	0.62	4/20
SCHEMBL339705	0.60	4/20
SCHEMBL1006768	0.59	4/20
SCHEMBL377080	0.55	4/20
SCHEMBL758009	0.54	4/20
SCHEMBL256490	0.54	4/20
SCHEMBL657488	0.49	4/20

Clinical trials — most relevant to SGMS2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Efficacy of Citicoline Eye Drops 2% on Visual Field Preservation in Patients With Open Angle Glaucoma	PHASE3	RECRUITING
Anti-inflammatory Pulmonal Therapy of Cystic Fibrosis (CF) Patients With Amitriptyline and Placebo	PHASE2	UNKNOWN
Anti-Inflammatory Pulmonal Therapy of CF-Patients With Amitriptyline and Placebo	PHASE2	COMPLETED
Lovaza's Effect on the Activation of Platelets	PHASE2	COMPLETED
Choline Effects - Pre-symptomatic AD	PHASE1	COMPLETED
Effect of Gemfibrozil on Serum Glycosylphosphatidylinositol (GPI) Phospholipase D and Triglycerides	PHASE1	COMPLETED
Sphingo-lipotoxicity and Trans-differentiation of Adipose Tissue in Obesity (SFINGOTRANS)	nan	COMPLETED
Evaluating the Association Between Sphingolipid Metabolites and Post-hepatectomy Liver Failure	nan	COMPLETED
Precision Medicine for Sng/Pain Control	nan	COMPLETED
Duality of Lipids: the Athlete's Paradox	nan	COMPLETED
Triglyceride-rich LIPoproteins and INflammatory Cytokines After Oral FAT Loading as Potential Early Biomarkers of the Risk of Progression Towards DIABETES and Development of Complications. LIPINFAT Diabetes Study.	nan	RECRUITING
Benefits of Eggs in Combination With a Plant-based Diet	nan	COMPLETED
Skeletal Muscle Diacylglycerol and Sphingolipids - Impact of Localization and Species on Insulin Resistance in Humans	nan	COMPLETED
Plasma Dihydroceramides Are Associated With Hepatic Steatosis in Type 1 and Type 2 Diabetes	nan	COMPLETED
Enpowering Progression Risk of Cerebral Amyloid Angiopathy	nan	COMPLETED
The ASTERS Study: Assessing the Role of Sphingolipids in AcuTE Respiratory Distress Syndrome (ARDS)	nan	COMPLETED
Translational Immunodiagnostics in Stroke (TrImS)	nan	RECRUITING
Egg Intake, Metabolic Outcomes and Choline Levels	nan	RECRUITING
Lipidomic and Multi-Omics Profiling of Fatty Liver Disease in People With and Without HIV	nan	NOT_YET_RECRUITING
Investigating the Metabolic and Lipidomic Profiles That Are Associated With Varying Grades of Diabetic Maculopathy and Retinopathy in South Wales	nan	RECRUITING
Evaluation of Plasma Sphingosine-1-Phosphate as A Diagnostic and Prognostic Biomarkers of Community-Acquired Pneumonia	nan	UNKNOWN
Androgens and NAFLD Longitudinal Cohort Study	nan	RECRUITING
Serum Sphingolipidomic Analyses in Healthy, Diabetic and Prediabetic Subjects	nan	UNKNOWN
Vulvodynia: Identification of Potential Relevant Biomarkers	nan	COMPLETED
Reducing Circulating Sphingolipid Levels to Optimise Cardiometabolic Health - The SphingoFIT Trial	nan	COMPLETED
Ceramide Level as Apredictor of Outcomes in Patients of Anterior Myocardial Infarction Undergoing Primary Coronary Intervention	nan	UNKNOWN
Effect of Plasma Ceramides on Peripheral Vascular Function	nan	COMPLETED
Plasma Sphingolipid Metabolites and Radiotherapy Efficacy in Hepatocellular Carcinoma	nan	RECRUITING
Rice Ceramide Supplementation and Skin Health	nan	COMPLETED
Metabolic Optimization Through Diet/Lifestyle Improvements For Youth	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a SGMS2 binder may also engage these)

Protein	Name	Similarity
Q9D4B1	—	1.000	Q9D4B1 →
Q4JM44	—	1.000	Q4JM44 →
Q4R763	—	1.000	Q4R763 →
Q8VCQ6	—	0.992	Q8VCQ6 →
A0AAS4	—	0.992	A0AAS4 →
Q7TSX5	—	0.990	Q7TSX5 →
SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	0.987	landscape →
Q7T3T4	—	0.985	Q7T3T4 →
Q20696	—	0.979	Q20696 →
Q9VS60	—	0.979	Q9VS60 →
Q9V576	—	0.975	Q9V576 →
Q60457	—	0.974	Q60457 →
P56079	—	0.973	P56079 →
O77761	—	0.972	O77761 →
Q99JY8	—	0.972	Q99JY8 →
O77760	—	0.971	O77760 →
SOAT1	Sterol O-acyltransferase 1	0.971	landscape →
Q20735	—	0.970	Q20735 →
Q61263	—	0.969	Q61263 →
Q8BUV8	—	0.969	Q8BUV8 →
Q7Z3F1	—	0.969	Q7Z3F1 →
Q94CA0	—	0.969	Q94CA0 →
Q5R9A7	—	0.968	Q5R9A7 →
Q10142	—	0.968	Q10142 →
P97544	—	0.967	P97544 →
P53439	—	0.967	P53439 →
O14495	—	0.967	O14495 →
Q500W7	—	0.967	Q500W7 →
A0A078H868	—	0.967	A0A078H868 →
O70536	—	0.966	O70536 →