Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | GLS2 | Q9UI32 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.30 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11122986 | 0.86 | ALDH1A1 (0.41) | USP2MAPTSMN1; SMN2ALDH1A1CYP3A4 | |
| SCHEMBL4016772 | 0.86 | USP2 (0.54) | USP2MAPTSMN1; SMN2ALDH1A1CYP3A4 | |
| SCHEMBL16265047 | 0.85 | TSHR (0.44) | USP2MAPTSMN1; SMN2ALDH1A1CYP3A4 | |
| SCHEMBL11515051 | 0.85 | USP2 (0.40) | USP2MAPTSMN1; SMN2ALDH1A1CYP3A4 | |
| SCHEMBL28434723 | 0.84 | USP2 (0.42) | USP2MAPTSMN1; SMN2ALDH1A1CYP3A4 | |
| SCHEMBL23668793 | 0.81 | TSHR (0.37) | MAPTSMN1; SMN2LMNAMEN1CYP1A2 | |
| SCHEMBL11041362 | 0.80 | USP2 (0.49) | USP2MAPTSMN1; SMN2ALDH1A1CYP3A4 | |
| SCHEMBL11124230 | 0.80 | USP2 (0.49) | USP2MAPTSMN1; SMN2ALDH1A1CYP3A4 | |
| SCHEMBL30722293 | 0.80 | TSHR (0.52) | USP2MAPTSMN1; SMN2ALDH1A1CYP3A4 | |
| SCHEMBL11121672 | 0.80 | USP2 (0.49) | USP2MAPTSMN1; SMN2ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4155908-A | PSORIASIS, ANTICOAGULANTS | MERCK & CO., INC. (US) | 1979-05-22 | — | — | US | disclosed |
| US-4128564-A | 9-Thia- and oxothia- and 9-dioxothia-11,12-seco-prostaglandins | MERCK & CO., INC. (US) | 1978-12-05 | — | — | US | disclosed |
| US-4085125-A | 9-Thia-, 9-oxothia-, and 9-dioxothia-11,12-seco-prostaglandins and processes | MERCK & CO., INC. (US) | 1978-04-18 | — | — | US | disclosed |
| US-4066675-A | PSORIASIS, THROMBOSIS | MERCK & CO., INC. (US) | 1978-01-03 | — | — | US | disclosed |
| US-4018802-A | SKIN DISEASES, GROWTH HORMONE STIMULANTS, THROMBUS PREVENTION, IMMUNOLOGY | MERCK & CO., INC. (US) | 1977-04-19 | — | — | US | disclosed |