Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 6/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.31 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.31 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3322726 | 0.98 | FDPS (0.40) | FDPSLMNADNM1OPRM1TSHR | |
| SCHEMBL3309107 | 0.98 | FDPS (0.40) | FDPSLMNADNM1OPRM1TSHR | |
| SCHEMBL3308065 | 0.98 | FDPS (0.40) | FDPSLMNADNM1OPRM1TSHR | |
| SCHEMBL3299938 | 0.98 | FDPS (0.40) | FDPSLMNADNM1OPRM1TSHR | |
| SCHEMBL3308446 | 0.98 | FDPS (0.40) | FDPSLMNADNM1OPRM1TSHR | |
| SCHEMBL3304517 | 0.98 | FDPS (0.40) | FDPSLMNADNM1OPRM1TSHR | |
| Iodide SCHEMBL11521345 | 0.96 | FDPS (0.39) | FDPSLMNADNM1OPRM1TSHR | |
| Hydrochloric Acid SCHEMBL5332198 | 0.96 | FDPS (0.39) | FDPSLMNADNM1OPRM1TSHR | |
| Hydrochloric Acid SCHEMBL11518440 | 0.96 | FDPS (0.39) | FDPSLMNADNM1OPRM1TSHR | |
| Hydrochloric Acid SCHEMBL8857458 | 0.96 | FDPS (0.39) | FDPSLMNADNM1OPRM1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4160116-A | FROM THE CORRESPONDING OXIDE BY HYDRATION USING ORGANIC PHOSPHONIUM HALIDE CATALYST, CARBON DIOXIDE | SHOWA DENKO K.K. (JP) | 1979-07-03 | — | — | US | disclosed |