SCHEMBL11520573

SCHEMBL11520573

CC(C)c1ccc(-c2cc(-c3ccccc3)sc2-c2ccc(C(C)C)cc2)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B1 P14061 2/20 0.54
ESR1 P03372 4/20 0.53
ESR2 Q92731 2/20 0.53
HSD17B2 P37059 1/20 0.45
PTP4A3 O75365 2/20 0.42
EP300 Q09472 1/20 0.41
PTP4A2 Q12974 1/20 0.40
PTP4A1 Q93096 1/20 0.40
MAPT P10636 3/20 0.39
SNCA P37840 1/20 0.39
RAB9A P51151 1/20 0.39
PAX8 Q06710 1/20 0.39
NOD2 Q9HC29 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
PTPN5 P54829 1/20 0.38
HDAC3 O15379 2/20 0.37
HDAC1 Q13547 2/20 0.37
HDAC2 Q92769 2/20 0.37
HDAC6 Q9UBN7 2/20 0.37
HDAC8 Q9BY41 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11520044 0.84 HSD17B1 (0.66) HSD17B1ESR1ESR2HSD17B2PTP4A3
SCHEMBL9755135 0.84 HSD17B1 (0.70) HSD17B1ESR1ESR2HSD17B2PTP4A3
SCHEMBL119652 0.81 HSD17B1 (0.58) HSD17B1ESR1ESR2HSD17B2PTP4A3
SCHEMBL11521308 0.81 HSD17B1 (0.58) HSD17B1ESR1ESR2HSD17B2PTP4A3
SCHEMBL11521978 0.81 HSD17B1 (0.58) HSD17B1ESR1ESR2HSD17B2PTP4A3
SCHEMBL11525349 0.81 HSD17B1 (0.58) HSD17B1ESR1ESR2HSD17B2PTP4A3
SCHEMBL27801961 0.81 HSD17B1 (0.58) HSD17B1ESR1ESR2HSD17B2PTP4A3
SCHEMBL11521678 0.81 HSD17B1 (0.58) HSD17B1ESR1ESR2HSD17B2PTP4A3
Hydrogen Sulfide SCHEMBL3010970 0.80 HSD17B1 (0.57) HSD17B1ESR1ESR2HSD17B2PTP4A3
SCHEMBL11522181 0.79 HSD17B1 (0.55) HSD17B1ESR1ESR2HSD17B2PTP4A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4174405-A MITICIDES UNIROYAL, INC. (US) 1979-11-13 US disclosed