Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MIF | P14174 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | CASP3 | P42574 | 2/20 | 0.45 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.45 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11517807 | 0.88 | SRD5A1 (0.51) | MAPTSMN1; SMN2RAB9AALDH1A1HPGD | |
| SCHEMBL11518114 | 0.81 | MIF (0.43) | MAPTSMN1; SMN2RAB9AALDH1A1HPGD | |
| SCHEMBL8142034 | 0.80 | SRD5A1 (0.56) | RAB9AALDH1A1HPGDKDM4EL3MBTL1 | |
| SCHEMBL11519977 | 0.78 | AKR1B1 (0.58) | MAPTSMN1; SMN2RAB9AALDH1A1HPGD | |
| SCHEMBL11516251 | 0.78 | AKR1B1 (0.46) | MAPTSMN1; SMN2ALDH1A1HPGDPOLB | |
| SCHEMBL9372469 | 0.77 | MAPK14 (0.57) | MAPTSMN1; SMN2RAB9AALDH1A1HPGD | |
| SCHEMBL11517083 | 0.77 | AKR1B1 (0.72) | MAPTSMN1; SMN2RAB9AALDH1A1HPGD | |
| SCHEMBL11521366 | 0.77 | POLB (0.43) | MAPTSMN1; SMN2RAB9AALDH1A1HPGD | |
| SCHEMBL7210611 | 0.74 | MAPT (0.50) | MAPTSMN1; SMN2ALDH1A1HPGDKDM4E | |
| SCHEMBL11518369 | 0.74 | POLB (0.43) | MAPTSMN1; SMN2ALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4172949-A | 2,4-Disubstituted-5-oxo-5H-dibenzo[a,d]cycloheptenes | SYNTEX (U.S.A.) INC. (US) | 1979-10-30 | — | — | US | disclosed |