Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MIF | P14174 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 9/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | CASP3 | P42574 | 2/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11517481 | 0.90 | AKR1B1 (0.55) | AKR1B1POLBMAOAMIFMAPT | |
| SCHEMBL11517083 | 0.89 | AKR1B1 (0.72) | AKR1B1POLBMAOAMIFMAPT | |
| SCHEMBL11520526 | 0.89 | AKR1B1 (0.54) | AKR1B1MAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL11517611 | 0.88 | AKR1B1 (0.53) | AKR1B1POLBMAOAMIFMAPT | |
| SCHEMBL11519573 | 0.87 | AKR1B1 (0.76) | AKR1B1POLBMAOAMIFMAPT | |
| SCHEMBL11843846 | 0.82 | AKR1B1 (0.51) | AKR1B1TDP1RAB9APTGS1PTGS2 | |
| SCHEMBL11519465 | 0.78 | AKR1B1 (0.69) | AKR1B1MAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL11523218 | 0.78 | MAPT (0.49) | AKR1B1POLBMAOAMIFMAPT | |
| SCHEMBL11520301 | 0.77 | AKR1B1 (0.68) | AKR1B1MAPTSMN1; SMN2LMNAMEN1 | |
| SCHEMBL11517807 | 0.77 | SRD5A1 (0.51) | AKR1B1POLBMAOAMIFMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4172949-A | 2,4-Disubstituted-5-oxo-5H-dibenzo[a,d]cycloheptenes | SYNTEX (U.S.A.) INC. (US) | 1979-10-30 | — | — | US | disclosed |