SCHEMBL11525429

SCHEMBL11525429

COc1ccc([C@H]2CC[C@H](c3ccc(C#N)cc3)CC2)cc1

nearest known ligand 0.50

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
KDM1A O60341 3/20 0.49
MAOA P21397 2/20 0.47
MAOB P27338 2/20 0.47
DRD2 P14416 1/20 0.47
HRH3 Q9Y5N1 4/20 0.45
CCR6 P51684 1/20 0.44
HRH2 P25021 1/20 0.44
HRH1 P35367 1/20 0.44
GRIA1 P42261 1/20 0.44
GRIA2 P42262 1/20 0.44
GRIA3 P42263 1/20 0.44
GRM2 Q14416 1/20 0.43
TDP1 Q9NUW8 1/20 0.42
CA1 P00915 1/20 0.42
CA2 P00918 1/20 0.42
CA9 Q16790 1/20 0.42
CA14 Q9ULX7 1/20 0.42
ALDH1A1 P00352 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11525435 1.00 KDM1A (0.49) KDM1AMAOAMAOBDRD2HRH3
SCHEMBL1515026 0.84 DRD2 (0.59) KDM1AMAOAMAOBDRD2CA1
SCHEMBL5958188 0.84 GRIA1 (0.49) MAOAMAOBHRH3GRIA1GRIA2
SCHEMBL11524666 0.83 HRH3 (0.48) MAOAMAOBHRH3HRH2HRH1
SCHEMBL11524662 0.83 HRH3 (0.48) MAOAMAOBHRH3HRH2HRH1
1,4-Dimethoxybenzene SCHEMBL28617696 0.82 MAOB (0.61) MAOAMAOBCA1CA2CA9
SCHEMBL103904 0.82 MAOB (0.61) MAOAMAOBCA1CA2CA9
SCHEMBL30757515 0.82 MAOB (0.61) MAOAMAOBCA1CA2CA9
SCHEMBL10343085 0.82 DRD2 (0.47) KDM1AMAOAMAOBDRD2GRM2
SCHEMBL10343086 0.82 DRD2 (0.47) KDM1AMAOAMAOBDRD2GRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4154697-A Liquid crystalline hexahydroterphenyl derivatives MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) 1979-05-15 US disclosed