Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.41 |
| ▸ | CCKBR | P32239 | 1/20 | 0.41 |
| ▸ | MC3R | P41968 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | GHSR | Q92847 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | BRD2 | P25440 | 1/20 | 0.40 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | F2RL3 | Q96RI0 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11526604 | 0.85 | LMNA (0.59) | LMNAHPGDPDE4DCHRM1GABRA1 | |
| SCHEMBL11525305 | 0.83 | LMNA (0.59) | LMNAHPGDPDE4DCHRM1GABRA1 | |
| Methane SCHEMBL11526611 | 0.81 | LMNA (0.59) | LMNAHPGDPDE4DCHRM1GABRA1 | |
| SCHEMBL11525302 | 0.80 | LMNA (0.57) | LMNAHPGDPDE4DCHRM1GABRA1 | |
| SCHEMBL11614838 | 0.74 | LMNA (0.55) | LMNAHPGDPDE4DCHRM1GABRA1 | |
| SCHEMBL11615590 | 0.74 | LMNA (0.57) | LMNAHPGDPDE4DCHRM1GABRA1 | |
| SCHEMBL11783935 | 0.73 | LMNA (0.64) | LMNAHPGDPDE4DCHRM1GABRA1 | |
| SCHEMBL11509112 | 0.73 | LMNA (0.64) | LMNAHPGDPDE4DCHRM1GABRA1 | |
| SCHEMBL11446036 | 0.73 | LMNA (0.56) | LMNAHPGDPDE4DCHRM1GABRA1 | |
| SCHEMBL11616066 | 0.73 | LMNA (0.53) | LMNAHPGDPDE4DCHRM1GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4157331-A | SEDATIVES, TRANQUILIZERS, ANTICONVULSANTS, MUSCLE RELAXANTS | HOFFMANN-LA ROCHE INC. (US) | 1979-06-05 | — | — | US | disclosed |
| US-4153799-A | ANXIOLYTICS, SEDATIVES, ANTICONVULSANTS, MUSCLE RELAXANTS, PYRAZOLE INTERMEDIATES | HOFFMANN-LA ROCHE INC. (US) | 1979-05-08 | — | — | US | disclosed |
| US-4130716-A | ANXIOLYTICS, SEDATIVE, MUSCLE RELAXANT, ANTICONVULSANT | HOFFMANN-LA ROCHE INC. (US) | 1978-12-19 | — | — | US | disclosed |