SCHEMBL11528508

SCHEMBL11528508

Cl[Si](Cl)(c1ccccc1)C1CC2C=CC1C2

nearest known ligand 0.36

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.36
TSHR P16473 1/20 0.36
ALDH1A1 P00352 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
LMNA P02545 1/20 0.31
CYP3A4 P08684 1/20 0.31
CYP2D6 P10635 1/20 0.31
HIF1A Q16665 1/20 0.31
CHRM2 P08172 1/20 0.31
CHRM4 P08173 1/20 0.31
CHRM1 P11229 1/20 0.31
CHRM3 P20309 1/20 0.31
PTGS2 P35354 1/20 0.31
HRH1 P35367 1/20 0.31
KCNH2 Q12809 1/20 0.31
HRH3 Q9Y5N1 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6701075 0.80 KDM4E (0.36) KDM4ETSHRALDH1A1TDP1LMNA
SCHEMBL6750638 0.79 KDM4E (0.36) KDM4ETSHRALDH1A1TDP1LMNA
Toluene SCHEMBL7034592 0.76 KDM4E (0.38) KDM4ETSHRALDH1A1TDP1LMNA
SCHEMBL5425486 0.75 KMT2A (0.34) KDM4ETSHRALDH1A1
SCHEMBL6697304 0.75 KDM4E (0.36) KDM4ETSHRALDH1A1TDP1LMNA
SCHEMBL6697436 0.75 KDM4E (0.36) KDM4ETSHRALDH1A1TDP1LMNA
SCHEMBL6695208 0.73 KDM4E (0.35) KDM4ETSHRALDH1A1TDP1LMNA
SCHEMBL18560853 0.72 KDM4E (0.32) KDM4ETSHR
SCHEMBL2605525 0.72 KDM4E (0.32) KDM4ETSHR
SCHEMBL21525762 0.72 KDM4E (0.32) KDM4ETSHRALDH1A1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4153765-A Curable composition containing EPM or EPDM interpolymers COPOLYMER RUBBER & CHEMICAL CORPORATION (US) 1979-05-08 US disclosed
US-4028483-A EPDM interpolymers formed with unsaturated organosilanes COPOLYMER RUBBER & CHEMICAL CORPORATION (US) 1977-06-07 US disclosed