SCHEMBL6701075

SCHEMBL6701075

C[Si](C)(c1ccccc1)C1CC2C=CC1C2

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.36
TSHR P16473 1/20 0.36
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
ALDH1A1 P00352 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
LMNA P02545 1/20 0.31
CYP3A4 P08684 1/20 0.31
CYP2D6 P10635 1/20 0.31
HIF1A Q16665 1/20 0.31
CHRM2 P08172 1/20 0.31
CHRM4 P08173 1/20 0.31
CHRM1 P11229 1/20 0.31
CHRM3 P20309 1/20 0.31
PTGS2 P35354 1/20 0.31
HRH1 P35367 1/20 0.31
KCNH2 Q12809 1/20 0.31
HRH3 Q9Y5N1 1/20 0.31
ESR1 P03372 1/20 0.31
ESR2 Q92731 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6750638 0.87 KDM4E (0.36) KDM4ETSHRMEN1KMT2AALDH1A1
SCHEMBL6695208 0.82 KDM4E (0.35) KDM4ETSHRMEN1KMT2AALDH1A1
SCHEMBL18560867 0.80 KDM4E (0.32) KDM4ETSHR
SCHEMBL21525765 0.80 KDM4E (0.32) KDM4ETSHR
SCHEMBL21525762 0.80 KDM4E (0.32) KDM4ETSHRMEN1KMT2AALDH1A1
SCHEMBL2605525 0.80 KDM4E (0.32) KDM4ETSHR
SCHEMBL18560853 0.80 KDM4E (0.32) KDM4ETSHR
SCHEMBL18587310 0.80 KDM4E (0.32) KDM4ETSHR
SCHEMBL11528508 0.80 KDM4E (0.36) KDM4ETSHRALDH1A1TDP1LMNA
SCHEMBL6697436 0.80 KDM4E (0.36) KDM4ETSHRMEN1KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9291901-B2 Amine treated maleic anhydride polymers with pendent silyl group, compositions and applications thereof SUMITOMO BAKELITE CO., LTD. (JP) 2016-03-22 US claimed
WO-2015038412-A2 AMINE TREATED MALEIC ANHYDRIDE POLYMERS WITH PENDENT SILYL GROUP, COMPOSITIONS AND APPLICATIONS THEREOF PROMERUS, LLC (US) 2015-03-19 WO claimed
US-20150079507-A1 AMINE TREATED MALEIC ANHYDRIDE POLYMERS WITH PENDENT SILYL GROUP, COMPOSITIONS AND APPLICATIONS THEREOF PROMERUS, LLC (US) 2015-03-19 US claimed
US-9291901-B2 Amine treated maleic anhydride polymers with pendent silyl group, compositions and applications thereof SUMITOMO BAKELITE CO., LTD. (JP) 2016-03-22 US disclosed
US-20150079507-A1 AMINE TREATED MALEIC ANHYDRIDE POLYMERS WITH PENDENT SILYL GROUP, COMPOSITIONS AND APPLICATIONS THEREOF PROMERUS, LLC (US) 2015-03-19 US disclosed
WO-2015038412-A2 AMINE TREATED MALEIC ANHYDRIDE POLYMERS WITH PENDENT SILYL GROUP, COMPOSITIONS AND APPLICATIONS THEREOF PROMERUS, LLC (US) 2015-03-19 WO disclosed
US-6777570-B2 Process for producing norbornene derivative having organosilyl group MITSUBISHI CHEMICAL CORPORATION (JP) 2004-08-17 US disclosed
US-20040063982-A1 Process for producing norbornene derivative having organosilyl group MITSUBISHI CHEMICAL CORPORATION (JP) 2004-04-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040063982-A1 Process for producing norbornene derivative having organosilyl group GRIA2, GRM2, GRM8 KDM4E 2658/4885TSHR 1793/4885MEN1 380/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.