Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.50 |
| ▸ | PLAU | P00749 | 16/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | SLC9A1 | P19634 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 0.39 |
| ▸ | SLC9A5 | Q14940 | 2/20 | 0.39 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11151830 | 0.84 | GRM5 (0.55) | GRM5PLAUCYP1A2CYP2D6TSHR | |
| SCHEMBL10087535 | 0.82 | PLAU (0.62) | PLAUCYP1A2CYP2D6TSHRSLC9A1 | |
| SCHEMBL11529197 | 0.81 | GRM5 (0.50) | GRM5PLAUCYP1A2CYP2D6TSHR | |
| SCHEMBL7851852 | 0.80 | GRM5 (0.56) | GRM5PLAUTDP1 | |
| SCHEMBL11528424 | 0.78 | ALDH1A1 (0.62) | GRM5PLAUCYP1A2CYP2D6TSHR | |
| SCHEMBL11478067 | 0.76 | GRM5 (0.56) | GRM5PLAUCYP1A2CYP2D6TSHR | |
| SCHEMBL11148721 | 0.76 | GRM5 (0.56) | GRM5PLAUCYP1A2CYP2D6TSHR | |
| Hydrochloric Acid SCHEMBL11618640 | 0.74 | PLAU (0.52) | GRM5PLAUCYP1A2CYP2D6TSHR | |
| SCHEMBL11528396 | 0.73 | CYP1A2 (0.68) | GRM5PLAUCYP1A2CYP2D6TSHR | |
| SCHEMBL11151450 | 0.73 | GRM5 (0.56) | GRM5PLAUCYP1A2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4145551-A | DIURETICS | MERCK & CO., INC. (US) | 1979-03-20 | — | — | US | claimed |