Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 6/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2131964 | 0.82 | TP53 (0.50) | SMN1; SMN2THRBTP53MAPTSMYD3 | |
| SCHEMBL2373540 | 0.80 | SMN1; SMN2 (0.49) | SMN1; SMN2THRBTP53MAPTSMYD3 | |
| SCHEMBL2619071 | 0.80 | THRB (0.48) | SMN1; SMN2THRBTP53MAPTSMYD3 | |
| SCHEMBL21939043 | 0.77 | THRB (0.56) | SMN1; SMN2THRBTP53MAPTSMYD3 | |
| SCHEMBL18255998 | 0.77 | MRGPRX4 (0.52) | SMN1; SMN2THRBTP53MAPTSMYD3 | |
| SCHEMBL14069154 | 0.77 | THRB (0.56) | SMN1; SMN2THRBTP53MAPTSMYD3 | |
| SCHEMBL16571478 | 0.76 | THRB (0.41) | SMN1; SMN2THRBTP53MAPTSMYD3 | |
| SCHEMBL6371541 | 0.76 | MAPT (0.56) | SMN1; SMN2THRBTP53MAPTHPGD | |
| SCHEMBL9892871 | 0.73 | THRB (0.42) | SMN1; SMN2THRBTP53MAPTSMYD3 | |
| SCHEMBL11726583 | 0.73 | SMN1; SMN2 (0.53) | SMN1; SMN2THRBTP53MAPTSMYD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4137321-A | Isoxazole carboxamides of m-aminotetramisole as anthelmintics | PFIZER INC. (US) | 1979-01-30 | — | — | US | disclosed |