Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLI1 | P08151 | 2/20 | 0.81 |
| ▸ | GLI2 | P10070 | 2/20 | 0.81 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.62 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.62 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CA4 | P22748 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.50 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.50 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.50 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.50 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13679147 | 0.86 | GLI1 (0.68) | GLI1GLI2PTGS2TRPV1PTGS1 | |
| SCHEMBL13182988 | 0.84 | POLB (0.68) | GLI1GLI2MEN1CYP2D6KMT2A | |
| SCHEMBL17040294 | 0.83 | GLI1 (0.64) | GLI1GLI2CYP2D6KMT2AFDFT1 | |
| SCHEMBL1891876 | 0.83 | PTGS1 (0.65) | GLI1GLI2PTGS2TRPV1PTGS1 | |
| SCHEMBL27598564 | 0.83 | PTGS1 (0.65) | GLI1GLI2PTGS2TRPV1PTGS1 | |
| SCHEMBL12608944 | 0.83 | GLI1 (0.64) | GLI1GLI2PTGS2TRPV1PTGS1 | |
| SCHEMBL17037435 | 0.81 | GLI1 (0.61) | GLI1GLI2FDFT1PLAAT3PLAAT5 | |
| SCHEMBL11533724 | 0.80 | PTGS1 (0.60) | GLI1GLI2PTGS2TRPV1PTGS1 | |
| SCHEMBL11531868 | 0.80 | PTGS1 (0.72) | GLI1GLI2PTGS2TRPV1PTGS1 | |
| SCHEMBL9878055 | 0.80 | PTGS1 (0.72) | GLI1GLI2PTGS2TRPV1PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4145557-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIPYRETICS | ELI LILLY AND COMPANY (US) | 1979-03-20 | — | — | US | disclosed |
| US-4062895-A | ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC | ELI LILLY AND COMPANY (US) | 1977-12-13 | — | — | US | disclosed |
| US-4001322-A | ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC | ELI LILLY AND COMPANY (US) | 1977-01-04 | — | — | US | disclosed |
| US-3972934-A | ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC | ELI LILLY AND COMPANY (US) | 1976-08-03 | — | — | US | disclosed |