SCHEMBL11533728

SCHEMBL11533728

CCC(C)C(c1ccccc1)(c1ccc(F)cc1)n1cncn1

nearest known ligand 0.38

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 10/20 0.38
KMT2A Q03164 1/20 0.36
CYP3A4 P08684 1/20 0.36
HSP90AA1 P07900 2/20 0.36
MLNR O43193 1/20 0.34
NR1I2 O75469 1/20 0.34
ADORA3 P0DMS8 1/20 0.34
TBXA2R P21731 1/20 0.34
CCKBR P32239 1/20 0.34
OPRK1 P41145 1/20 0.34
SLC6A3 Q01959 1/20 0.34
KCNH2 Q12809 1/20 0.34
NR1H4 Q96RI1 1/20 0.34
CYP17A1 P05093 2/20 0.33
LMNA P02545 1/20 0.31
MAPT P10636 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11534655 0.92 HSP90AA1 (0.41) CYP19A1KMT2AHSP90AA1CYP17A1LMNA
SCHEMBL11536075 0.87 TSHR (0.38) CYP19A1KMT2ACYP3A4HSP90AA1
SCHEMBL11531851 0.81 HSP90AA1 (0.35) CYP19A1KMT2AHSP90AA1LMNAMAPT
SCHEMBL11534339 0.79 CYP19A1 (0.60) CYP19A1KMT2ACYP3A4HSP90AA1MLNR
SCHEMBL11530495 0.77 CYP19A1 (0.49) CYP19A1KMT2ACYP3A4HSP90AA1MLNR
SCHEMBL11531946 0.77 HSP90AA1 (0.41) CYP19A1KMT2AHSP90AA1LMNAMAPT
SCHEMBL11533864 0.77 MEN1 (0.37) CYP19A1KMT2ACYP3A4HSP90AA1LMNA
SCHEMBL11531549 0.77 CYP19A1 (0.41) CYP19A1KMT2ACYP3A4HSP90AA1LMNA
SCHEMBL11533125 0.76 CYP19A1 (0.57) CYP19A1KMT2ACYP3A4HSP90AA1MLNR
SCHEMBL11534213 0.75 CYP19A1 (0.47) CYP19A1KMT2ACYP3A4HSP90AA1MLNR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4140782-A Combating fungi and nematodes with diphenyl-triazolyl-methanes BAYER AKTIENGESELLSCHAFT (DE) 1979-02-20 US disclosed