Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 3/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 5/20 | 0.48 |
| ▸ | GLA | P06280 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27188738 | 0.78 | KDM4E (0.53) | KDM4ERAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL4445353 | 0.78 | KDM4E (0.61) | KDM4ERAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL29615690 | 0.78 | KDM4E (0.61) | KDM4ERAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL28373617 | 0.73 | NPC1 (0.50) | KDM4ERAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL14082011 | 0.72 | KDM4E (0.58) | KDM4ERAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL15886688 | 0.72 | KDM4E (0.75) | KDM4ERAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL4814056 | 0.72 | RAB9A (0.46) | KDM4ERAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL4814350 | 0.71 | KDM4E (0.42) | KDM4ERAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL6712742 | 0.71 | NPC1 (0.46) | KDM4ERAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL882702 | 0.70 | MAPT (0.47) | KDM4ERAB9ANPC1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4180580-A | HYPOTENSIVE AGENTS, MICROBIOCIDES | AMERICAN HOME PRODUCTS CORP. (US) | 1979-12-25 | — | — | US | disclosed |
| US-4108998-A | ANTIMICROBIAL, HYPOTENSIVE AGENTS | AMERICAN HOME PRODUCTS CORP. (US) | 1978-08-22 | — | — | US | disclosed |