Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 4/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.46 |
| ▸ | HTR1A | P08908 | 3/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11533521 | 1.00 | KCNA3 (0.55) | KCNA3CYP2D6CHRM2CHRM1KCNH2 | |
| SCHEMBL11539299 | 0.99 | KCNA3 (0.53) | KCNA3CYP2D6CHRM2CHRM1KCNH2 | |
| SCHEMBL11487964 | 0.93 | KCNA3 (0.48) | KCNA3CYP2D6CHRM2CHRM1KCNH2 | |
| SCHEMBL11533605 | 0.93 | KCNA3 (0.50) | KCNA3CYP2D6CHRM2CHRM1KCNH2 | |
| SCHEMBL11480207 | 0.92 | KCNA3 (0.46) | KCNA3CYP2D6CHRM2CHRM1KCNH2 | |
| SCHEMBL11531635 | 0.88 | OPRM1 (0.46) | KCNA3OPRM1LMNARAB9ANPSR1 | |
| SCHEMBL11537461 | 0.88 | KCNA3 (0.41) | KCNA3CYP2D6MAPK1MEN1KMT2A | |
| SCHEMBL11478737 | 0.87 | KCNA3 (0.44) | KCNA3CYP2D6MAPK1SIGMAR1 | |
| SCHEMBL11537904 | 0.85 | KCNA3 (0.44) | KCNA3CYP2D6CHRM2CHRM1KCNH2 | |
| SCHEMBL11532046 | 0.84 | CYP2D6 (0.46) | KCNA3CYP2D6CHRM2CHRM1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4153797-A | α-Aryl-α, α-bis[ω- (disubstituted amino)alkyl]acetamides and related compounds | G. D. SEARLE & CO. (US) | 1979-05-08 | — | — | US | disclosed |
| US-4107205-A | α-Aryl-α,α-bis[ω-(disubstituted amino)alkyl]acetamides and related compounds | G. D. SEARLE & CO. (US) | 1978-08-15 | — | — | US | disclosed |