Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | AHR | P35869 | 1/20 | 0.47 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | HK1 | P19367 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | GALK1 | P51570 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.47 |
| ▸ | HTR5A | P47898 | 4/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6285150 | 0.82 | HTR5A (0.41) | RAB9AKDM4EMEN1MAPTKMT2A | |
| SCHEMBL21214242 | 0.80 | MEN1 (0.43) | NPC1RAB9AAHRPDK2KDM4E | |
| SCHEMBL12330258 | 0.80 | HTR5A (0.40) | HTR5ACREBBPGRIA1CACNG8DAO | |
| SCHEMBL12086510 | 0.80 | GRIA1 (0.42) | NPC1RAB9AHTR5ACREBBPLMNA | |
| SCHEMBL13456181 | 0.79 | NPC1 (0.46) | NPC1RAB9AAHRPDK2KDM4E | |
| SCHEMBL12330257 | 0.78 | NPC1 (0.41) | NPC1RAB9AAHRPDK2KDM4E | |
| SCHEMBL5141694 | 0.77 | NPC1 (0.47) | NPC1RAB9AAHRPDK2KDM4E | |
| SCHEMBL11534863 | 0.77 | AHR (0.59) | NPC1RAB9AAHRPDK2KDM4E | |
| SCHEMBL11535714 | 0.77 | HTR5A (0.50) | NPC1RAB9AAHRPDK2KDM4E | |
| SCHEMBL30228472 | 0.77 | HTR5A (0.50) | NPC1RAB9AAHRPDK2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3116860-B1 | SULFONAMIDES DERIVED FROM TRICYCLYL-2-AMINOCYCLOALKANOLS AS ANTICANCER AGENTS | ICAHN SCHOOL MED MOUNT SINAI (US) | 2018-02-07 | — | — | EP | disclosed |
| US-4132794-A | 10-Imidoylacridan compositions | MEAD JOHNSON & COMPANY (US) | 1979-01-02 | — | — | US | disclosed |
| US-4115571-A | DIURETICS, SMOOTH MUSCLE RELAXANTS, ANTITHROMBOGENIC AGENTS | MEAD JOHNSON & COMPANY (US) | 1978-09-19 | — | — | US | disclosed |
| US-4094981-A | SMOOTH MUSCLE RELAXANT EMPLOYING 10-IMIDOYLACRIDANS | MEAD JOHNSON & COMPANY (US) | 1978-06-13 | — | — | US | disclosed |
| US-4077959-A | DIURETICS, SMOOTH MUSCLE RELAXANTS, ANTITHROMBOGENIC | MEAD JOHNSON & COMPANY (US) | 1978-03-07 | — | — | US | disclosed |
| US-4046891-A | Smooth muscle relaxant process employing 10-imidoylphenoxazines | MEAD JOHNSON & COMPANY (US) | 1977-09-06 | — | — | US | disclosed |
| US-3962252-A | 10-IMIDOYLACRIDANS | MEAD JOHNSON & COMPANY (US) | 1976-06-08 | — | — | US | disclosed |
| US-3946004-A | DIURETICS, MUSCLE RELAXANTS, ANTITHROMBOGENIC AGENTS | MEAD JOHNSON & COMPANY (US) | 1976-03-23 | — | — | US | disclosed |