Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 2/20 | 0.58 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.56 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | VCP | P55072 | 4/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | EIF2S1 | P05198 | 1/20 | 0.44 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19090781 | 0.84 | PRKCI (0.55) | PRKCINAPRTVCPP2RX7ALDH1A1 | |
| SCHEMBL165047 | 0.81 | MAPK8 (0.48) | ALOX5MAPK8P2RX7PDE4AKCNH2 | |
| SCHEMBL268777 | 0.81 | P2RX7 (0.65) | MAPK8P2RX7PDE4AKCNH2ALDH1A1 | |
| SCHEMBL26336039 | 0.81 | MAPK8 (0.48) | ALOX5MAPK8P2RX7PDE4AKCNH2 | |
| SCHEMBL1232303 | 0.81 | PRKCI (0.63) | PRKCINAPRTVCPP2RX7LMNA | |
| SCHEMBL27559774 | 0.81 | KDM4E (0.46) | ALOX5MAPK8P2RX7PDE4AKCNH2 | |
| SCHEMBL24571401 | 0.80 | SMN1; SMN2 (0.56) | ALDH1A1LMNAMAPTHPGDSMN1; SMN2 | |
| SCHEMBL27986290 | 0.80 | MAPK8 (0.47) | MAPK8P2RX7PDE4AKCNH2ALDH1A1 | |
| SCHEMBL21209660 | 0.80 | NAPRT (0.56) | NAPRTALOX5MAPK8P2RX7PDE4A | |
| SCHEMBL11906279 | 0.80 | KDM4E (0.51) | PRKCIMAPK8PDE4AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115969846-B | Application of small molecule compound LZ-10 in preparation of medicine for treating and/or preventing optic neuritis lineage diseases | 上海中医药大学附属岳阳中西医结合医院 | 2024-04-12 | — | — | CN | claimed |
| CN-115969846-A | Application of small molecule compound LZ-10 in preparing medicine for treating and/or preventing optic neuritis pedigree diseases | 上海中医药大学附属岳阳中西医结合医院 | 2023-04-18 | — | — | CN | claimed |
| CN-115969846-B | Application of small molecule compound LZ-10 in preparation of medicine for treating and/or preventing optic neuritis lineage diseases | 上海中医药大学附属岳阳中西医结合医院 | 2024-04-12 | — | — | CN | disclosed |
| CN-115969846-A | Application of small molecule compound LZ-10 in preparing medicine for treating and/or preventing optic neuritis pedigree diseases | 上海中医药大学附属岳阳中西医结合医院 | 2023-04-18 | — | — | CN | disclosed |
| CN-102574845-A | 1h-imidazo[4,5-c]quinolinone derivatives | NOVARTIS AG | 2012-07-11 | — | — | CN | disclosed |
| US-4175184-A | Manufacture of 2,1,3-thiadiazin-4-one-2,2-dioxide derivatives | BASF AKTIENGESELLSCHAFT (DE) | 1979-11-20 | — | — | US | disclosed |
| US-3947442-A | Method for producing heterocyclic acid anhydrides and pyrimidinediones | THE SHERWIN-WILLIAMS COMPANY (US) | 1976-03-30 | — | — | US | disclosed |
| US-3947416-A | Azaisatoic anhydrides | THE SHERWIN-WILLIAMS COMPANY (US) | 1976-03-30 | — | — | US | disclosed |