Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 6/20 | 0.59 |
| ▸ | SLC6A4 known ✓ | P31645 | 6/20 | 0.59 |
| ▸ | CHRM2 known ✓ | P08172 | 5/20 | 0.59 |
| ▸ | SLC6A3 known ✓ | Q01959 | 5/20 | 0.49 |
| ▸ | ADRA2B known ✓ | P18089 | 3/20 | 0.49 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 2/20 | 0.49 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.49 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.49 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.49 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.49 |
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.49 |
| ▸ | SCN1A | P35498 | 3/20 | 0.59 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.59 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.49 |
| ▸ | HRH1 | P35367 | 4/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.49 |
| ▸ | HTR2A | P28223 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20385529 | 0.92 | SLC6A2 (0.64) | SLC6A2SLC6A4CHRM2SCN1ASCN2A | |
| SCHEMBL5321828 | 0.90 | SLC6A2 (0.49) | SLC6A2SLC6A4CHRM2SCN1ASCN2A | |
| SCHEMBL28569942 | 0.90 | CHRM2 (0.52) | SLC6A2SLC6A4CHRM2SCN1ASCN2A | |
| SCHEMBL28569939 | 0.90 | CHRM2 (0.52) | SLC6A2SLC6A4CHRM2SCN1ASCN2A | |
| SCHEMBL659244 | 0.89 | SLC6A2 (0.50) | SLC6A2SLC6A4CHRM2SCN1ASCN2A | |
| Bromide SCHEMBL28540730 | 0.82 | TSHR (0.50) | SLC6A2SLC6A4CHRM2SCN1ASCN2A | |
| Bromide SCHEMBL28986874 | 0.81 | KCNA5 (0.46) | SLC6A2SLC6A4CHRM2SCN1ASCN2A | |
| Bromide SCHEMBL19032332 | 0.81 | KCNA5 (0.46) | SLC6A2SLC6A4CHRM2SCN1ASCN2A | |
| SCHEMBL28193271 | 0.81 | CHRM2 (0.41) | SLC6A2SLC6A4CHRM2SCN1ASCN2A | |
| SCHEMBL22374013 | 0.80 | TSHR (0.51) | SLC6A2SLC6A4CHRM2SCN1ASCN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4146573-A | RED MUD TREATMENT | NALCO CHEMICAL COMPANY (US) | 1979-03-27 | — | — | US | disclosed |